MOAP1 抗体 (Center)
Quick Overview for MOAP1 抗体 (Center) (ABIN500228)
抗原
See all MOAP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Center
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特异性
- This antibody detects Modulator of apoptosis 1 at enter.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse
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纯化方法
- Peptide affinity chromatography
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免疫原
- MAP-1 antibody was raised against a 15 amino acid peptide from near the center of human MAP-1.
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亚型
- IgG
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anti-Modulator of Apoptosis 1 (MOAP1) (AA 1-351) antibody
MOAP1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4A1 unconjugated
anti-Modulator of Apoptosis 1 (MOAP1) (AA 1-351) antibodyMOAP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Modulator of Apoptosis 1 (MOAP1) (AA 1-351) antibodyMOAP1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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ELISA. Western blot: 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- MOAP1 (Modulator of Apoptosis 1 (MOAP1))
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别名
- MOAP1
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背景
- Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains (reviewed in 2 and 3). A related protein termed MAP-1 has recently been identified. This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed. It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo (4). It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis (5).Synonyms: MAP-1, MAP1, Modulator of apoptosis 1
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基因ID
- 64112
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NCBI登录号
- NP_071434
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UniProt
- Q96BY2
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途径
- Positive Regulation of Endopeptidase Activity
抗原
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