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LSD1 抗体 (Center)

Name: LSD1 抗体 (Center)
SKU: ABIN500200
Availability: OutOfStock

KDM1A 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated

Western blot analysis of LSD1 in P815 cell lysate with this product at (A) 1 and (B) 2 μg/ml. (LSD1 抗体 (Center))

Immunohistochemistry of LSD1 in human small intestine tissue with this product at 2 μg/ml. (LSD1 抗体 (Center))

IHC (p)

2 images

产品编号 ABIN500200

发货至: 中国

Datasheet as PDF

抗原 See all LSD1 (KDM1A) 抗体

LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))
抗原表位
15

8

7

6

4

3

3

3

2

2

2

2

1

1

1

1

1

1

1

1

1
Center
适用
78

37

29

6

3

2

1

1

1

1

1

1

1
人, 小鼠, 大鼠
宿主
61

16

1

1
兔
Compatible Secondaries
克隆类型
62

18
多克隆
标记
60

3

3

3

1

1

1

1

1

1

1

1

1

1

1
This LSD1 antibody is un-conjugated
应用范围
72

36

26

22

19

13

13

12

6

5

4

4

3

2

2

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

特异性

This antibody detects LSD1 at center.

交叉反应（详细）

Species reactivity (tested):Human, mouse, rat

纯化方法

Peptide affinity chromatography

免疫原

LSD1 antibody was raised against a 16 amino acid peptide from near the center of human LSD1.

亚型

IgG

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anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 55-263) antibody
KDM1A 适用: 人, 猴 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 3F9A3 unconjugated

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 753-851) antibody
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anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 108-142) antibody
KDM1A 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 819-852) antibody
KDM1A 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 819-852), (C-Term) antibody
KDM1A 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB7583 unconjugated

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 100-150) antibody
KDM1A 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

应用备注

ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
缓冲液

PBS containing 0.02 % sodium azide

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
抗原

LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))

别名

AOF2 (KDM1A 产品)

别名

AOF2 antibody, BHC110 antibody, KDM1 antibody, LSD1 antibody, 1810043O07Rik antibody, AA408884 antibody, Aof2 antibody, D4Ertd478e antibody, Kdm1 antibody, Lsd1 antibody, mKIAA0601 antibody, DKFZp459N2450 antibody, RGD1562975 antibody, aof2 antibody, kdm1 antibody, wu:fb82e06 antibody, wu:fc51a02 antibody, wu:fj36a05 antibody, wu:fj66b06 antibody, KDM1A antibody, lsd1 antibody, xLSD1 antibody, AtLSD1 antibody, F9F13.30 antibody, F9F13_30 antibody, LESION SIMULATING DISEASE antibody, LESION SIMULATING DISEASE 1 antibody, lysine demethylase 1A antibody, lysine (K)-specific demethylase 1A antibody, lysine (K)-specific demethylase 1a antibody, LSD1 zinc finger family protein antibody, KDM1A antibody, Kdm1a antibody, kdm1a antibody, LSD1 antibody

背景

Histone modifications mediate changes in gene expression by altering chromatin structure or by serving as a platform to recruit other proteins. LSD1 is a recently discovered amine oxidase that catalyzes the lysine-specific demethylation of histone proteins via an FAD-dependent oxidative reaction (1). Methylation on histone H3-K9 is thought to play an important role in heterochromatin formation, while methylation on arginine and some lysine residues (such as H3-K4) is associated with active transcription (2). LSD1 associates with various proteins, including HDAC1/2, CoREST, and BHC80, that act to regulate LSD1 activity in vivo, and in a histone H3-K4-specific methylase complex that is involved in transcriptional regulation (3,4). Experiments have shown that CoREST, a SANT domain-containing corepressor (5) acts to enhance LSD1 activity, while BHC80, a PHD domain-containing protein (6), inhibits CoREST/LSD1 activity in vitro (3). LSD1-mediated histone demethylation thus may have significant effects on gene expression.Synonyms: BRAF35-HDAC complex protein BHC110, Flavin-containing amine oxidase domain-containing protein 2, KIAA0601, LSD1, Lysine-specific histone demethylase 1

基因ID

23028

NCBI登录号

NP_055828

UniProt

O60341

途径

Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Negative Regulation of intrinsic apoptotic Signaling, Warburg Effect