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LSD1 抗体 (N-Term)

This anti-LSD1 antibody is a 兔 多克隆 antibody detecting LSD1 in WB 和 EIA. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN500198
发货至: 中国

Quick Overview for LSD1 抗体 (N-Term) (ABIN500198)

抗原

See all LSD1 (KDM1A) 抗体
LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

  • 58
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多克隆

标记

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This LSD1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Enzyme Immunoassay (EIA)
  • 抗原表位

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    N-Term

    特异性

    This antibody detects LSD1 at N-term.

    交叉反应 (详细)

    Species reactivity (tested):Human, mouse, rat

    纯化方法

    Peptide affinity chromatography

    免疫原

    LSD1 antibody was raised against a 17 amino acid peptide from near the amino terminus of human LSD1.

    亚型

    IgG
  • 应用备注

    ELISA. Western blot: 1 - 2 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 缓冲液

    PBS containing 0.02 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • 抗原

    LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))

    别名

    AOF2

    背景

    Histone modifications mediate changes in gene expression by altering chromatin structure or by serving as a platform to recruit other proteins. LSD1 is a recently discovered amine oxidase that catalyzes the lysine-specific demethylation of histone proteins via an FAD-dependent oxidative reaction (1). Methylation on histone H3-K9 is thought to play an important role in heterochromatin formation, while methylation on arginine and some lysine residues (such as H3-K4) is associated with active transcription (2). LSD1 associates with various proteins, including HDAC1/2, CoREST, and BHC80, that act to regulate LSD1 activity in vivo, and in a histone H3-K4-specific methylase complex that is involved in transcriptional regulation (3,4). Experiments have shown that CoREST, a SANT domain-containing corepressor (5) acts to enhance LSD1 activity, while BHC80, a PHD domain-containing protein (6), inhibits CoREST/LSD1 activity in vitro (3). LSD1-mediated histone demethylation thus may have significant effects on gene expression.Synonyms: BRAF35-HDAC complex protein BHC110, Flavin-containing amine oxidase domain-containing protein 2, KIAA0601, LSD1, Lysine-specific histone demethylase 1

    基因ID

    23028

    NCBI登录号

    NP_055828

    UniProt

    O60341

    途径

    Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Negative Regulation of intrinsic apoptotic Signaling, Warburg Effect
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