IRGM 抗体 (N-Term)
This anti-IRGM antibody is a 兔 多克隆 antibody detecting IRGM in WB 和 EIA. Suitable for 人, 小鼠 和 大鼠.
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Quick Overview for IRGM 抗体 (N-Term) (ABIN500068)
抗原
See all IRGM 抗体
IRGM
(Immunity-Related GTPase Family, M (IRGM))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This IRGM antibody is un-conjugated
应用范围
Western Blotting (WB), Enzyme Immunoassay (EIA)
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抗原表位
- N-Term
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特异性
- This antibody detects IRGM at N-term.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Peptide affinity chromatography
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免疫原
- IRGM antibody was raised against a 17 amino acid peptide near the amino terminus of the human IRGM.
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亚型
- IgG
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anti-Immunity-Related GTPase Family, M (IRGM) (AA 151-179), (C-Term) antibody
IRGM 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB20841 unconjugated
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应用备注
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ELISA. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- IRGM (Immunity-Related GTPase Family, M (IRGM))
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别名
- IRGM / LRG-47
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背景
- Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins thought to be critical to the autophagy pathway and being significantly associated with Crohn's disease. In mouse, IRGM belongs to a family of gamma-interferon-induced GTP-binding proteins of approximately 48 kDa. Murine IRGM induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. Human IRGM is also involved in autophagy and plays a role in the control of intracellular pathogens and in the reduction of intracellular bacillary load.Synonyms: IFI1, IRGM1, Immunity-related GTPase family M protein, Immunity-related GTPase family M protein 1, Interferon-inducible protein 1, LRG47
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基因ID
- 345611
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UniProt
- F8VPC9
抗原
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