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IRF8 抗体

IRF8 适用: 人, 小鼠, 大鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN500062
发货至: 中国
  • 抗原 See all IRF8 抗体
    IRF8 (Interferon Regulatory Factor 8 (IRF8))
    适用
    • 31
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    人, 小鼠, 大鼠
    宿主
    • 43
    • 2
    • 1
    克隆类型
    • 45
    • 1
    多克隆
    标记
    • 32
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    • 1
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    This IRF8 antibody is un-conjugated
    应用范围
    • 26
    • 17
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    • 3
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    Western Blotting (WB), Enzyme Immunoassay (EIA)
    特异性
    IRF8 antibody was raised against a peptide corresponding to 16 amino acids near the carboxy-terminus of human IRF8.
    纯化方法
    Affinity chromatography purified via peptide column
    免疫原
    Human IRF8 Peptide
    亚型
    IgG
    Top Product
    Discover our top product IRF8 Primary Antibody
  • 应用备注
    ELISA. Western Blot: 1 - 2 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 缓冲液
    PBS containing 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store the antibody undiluted at 2-8 °C.
  • 抗原
    IRF8 (Interferon Regulatory Factor 8 (IRF8))
    别名
    IRF8 / ICSBP1 (IRF8 产品)
    别名
    zgc:92252 antibody, IRF8 antibody, MGC140338 antibody, DKFZp469B0320 antibody, H-ICSBP antibody, ICSBP antibody, ICSBP1 antibody, IRF-8 antibody, icsbp1 antibody, AI893568 antibody, Icsbp1 antibody, Myls antibody, interferon regulatory factor 8 antibody, interferon regulatory factor 8 L homeolog antibody, irf8 antibody, IRF8 antibody, irf8.L antibody, Irf8 antibody
    背景
    Interferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms (1 for review). During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. Unlike IRF3, IRF8 appears to act as a negative regulator of IFN-induced genes in most cases (2,3), but IRF8 mediates activation of NF-kappaB by the toll-like receptor 9 (TLR9) after stimulation by unmethylated CpG DNA in dendritic cells (4,5). Finally, it has been shown that IRF8 decreases bcl-2 expression and thus may play a role in chronic myelogenous leukemia (6).Synonyms: IRF-8, Interferon consensus sequence-binding protein, Interferon regulatory factor 8
    基因ID
    3394
    NCBI登录号
    NP_002154
    UniProt
    Q02556
    途径
    Cellular Response to Molecule of Bacterial Origin
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