IRF8 抗体
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- 抗原 See all IRF8 抗体
- IRF8 (Interferon Regulatory Factor 8 (IRF8))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This IRF8 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- 特异性
- IRF8 antibody was raised against a peptide corresponding to 16 amino acids near the carboxy-terminus of human IRF8.
- 纯化方法
- Affinity chromatography purified via peptide column
- 免疫原
- Human IRF8 Peptide
- 亚型
- IgG
- Top Product
- Discover our top product IRF8 Primary Antibody
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- 应用备注
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ELISA. Western Blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 缓冲液
- PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C.
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- 抗原
- IRF8 (Interferon Regulatory Factor 8 (IRF8))
- 别名
- IRF8 / ICSBP1 (IRF8 产品)
- 别名
- zgc:92252 antibody, IRF8 antibody, MGC140338 antibody, DKFZp469B0320 antibody, H-ICSBP antibody, ICSBP antibody, ICSBP1 antibody, IRF-8 antibody, icsbp1 antibody, AI893568 antibody, Icsbp1 antibody, Myls antibody, interferon regulatory factor 8 antibody, interferon regulatory factor 8 L homeolog antibody, irf8 antibody, IRF8 antibody, irf8.L antibody, Irf8 antibody
- 背景
- Interferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms (1 for review). During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. Unlike IRF3, IRF8 appears to act as a negative regulator of IFN-induced genes in most cases (2,3), but IRF8 mediates activation of NF-kappaB by the toll-like receptor 9 (TLR9) after stimulation by unmethylated CpG DNA in dendritic cells (4,5). Finally, it has been shown that IRF8 decreases bcl-2 expression and thus may play a role in chronic myelogenous leukemia (6).Synonyms: IRF-8, Interferon consensus sequence-binding protein, Interferon regulatory factor 8
- 基因ID
- 3394
- NCBI登录号
- NP_002154
- UniProt
- Q02556
- 途径
- Cellular Response to Molecule of Bacterial Origin
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