NLRC4 抗体
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北京 101111
Quick Overview for NLRC4 抗体 (ABIN500034)
抗原
See all NLRC4 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- Ipaf antibody was raised against a synthetic peptide corresponding to amino acids near the C-terminus of human Ipaf.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- Human Ipaf / CARD12 / CLANA Peptide
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亚型
- IgG
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应用备注
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ELISA. Western Blot: 0.5 to 2 μg/mL. Human peripheral blood leukocyte (PBL) cell lysate can beused as positive control and a 110 kDa band can be detected. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- NLRC4 (NLR Family, CARD Domain Containing 4 (NLRC4))
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别名
- NLRC4
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背景
- Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adaptor molecules and proteases including several members of the caspase family. Another family of proteins that functions as a critical regulator of apoptosis and NF-kappaB signaling pathways is the CED-4/Apaf-1 (apoptosis protein activating factor-1) protein family (1). Ipaf (ICE protease activating factor) is a CED-4/Apaf-1 family member that activates caspase-1/ICE and can induce apoptosis in human cells in a caspase-1 dependent manner (2,3). Ipaf and caspase-1 are thought to interact with each other through the association of the Ipaf amino-terminal CARD (caspase recruitment domain) and amino-terminal CARD of caspase-1.Synonyms: CARD12, CLAN, CLAN1, IPAF, NLR family CARD domain-containing protein 4
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基因ID
- 58484
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NCBI登录号
- NP_067032
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UniProt
- Q9NPP4
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途径
- Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome
抗原
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