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IL-33 抗体 (N-Term)

This anti-IL-33 antibody is a 兔 多克隆 antibody detecting IL-33 in WB, IF 和 EIA. Suitable for 人.
产品编号 ABIN500012
发货至: 中国

Quick Overview for IL-33 抗体 (N-Term) (ABIN500012)

抗原

See all IL-33 (IL33) 抗体
IL-33 (IL33) (Interleukin 33 (IL33))

适用

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宿主

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克隆类型

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多克隆

标记

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This IL-33 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
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    N-Term

    特异性

    This antibody reacts to IL-33.

    纯化方法

    Affinity chromatography purified via peptide column

    免疫原

    IL-33 antibody was raised against a 19 amino acid peptide from near the amino terminus of human IL-33.

    亚型

    IgG
  • 应用备注

    ELISA. Western Blot: 1 μg/mL. Immunofluorescence.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 缓冲液

    PBS containing 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C
  • 抗原

    IL-33 (IL33) (Interleukin 33 (IL33))

    别名

    Interleukin-33 (IL33)

    背景

    Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1a/b, IL-1Ra and IL-18. Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling and IL-1R accessory protein (IL-1RAcP). Receptor binding of IL-33 activates NF-kappaB and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. Despite its predicted molecular weight, IL-33 will often run at higher molecular weight in SDS-PAGE.Synonyms: C9orf26, IL-1F11, IL-33, IL1F11, Interleukin-1 family member 11, NF-HEV, NFHEV, Nuclear factor from high endothelial venules

    基因ID

    90865

    NCBI登录号

    NP_254274

    UniProt

    O95760

    途径

    Production of Molecular Mediator of Immune Response
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