IL-31 抗体 (N-Term)
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北京 101111
Quick Overview for IL-31 抗体 (N-Term) (ABIN500004)
抗原
See all IL-31 (IL31) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- IL-31 antibody was raised against a 16 amino acid peptide from near the amino terminus of mouse IL-31.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- Murine IL-31 (N-Terminus) Peptide
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亚型
- IgG
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应用备注
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ELISA. Western Blot: 2.5 - 5 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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- IL-31 (IL31) (Interleukin 31 (IL31))
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别名
- Interleukin-31 / IL31
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背景
- Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells (1,2). IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor (2). In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways (3). RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells . IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development (1,4).Synonyms: IL-31
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基因ID
- 76399
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UniProt
- Q6EAL8
抗原
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