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IL-31 抗体 (N-Term)

This anti-IL-31 antibody is a 兔 多克隆 antibody detecting IL-31 in WB, IHC (p) 和 EIA. Suitable for 小鼠.
产品编号 ABIN500004
发货至: 中国

Quick Overview for IL-31 抗体 (N-Term) (ABIN500004)

抗原

See all IL-31 (IL31) 抗体
IL-31 (IL31) (Interleukin 31 (IL31))

适用

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小鼠

宿主

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克隆类型

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多克隆

标记

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This IL-31 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
  • 抗原表位

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    N-Term

    特异性

    IL-31 antibody was raised against a 16 amino acid peptide from near the amino terminus of mouse IL-31.

    纯化方法

    Affinity chromatography purified via peptide column

    免疫原

    Murine IL-31 (N-Terminus) Peptide

    亚型

    IgG
  • 应用备注

    ELISA. Western Blot: 2.5 - 5 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 缓冲液

    PBS containing 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C
  • 抗原

    IL-31 (IL31) (Interleukin 31 (IL31))

    别名

    Interleukin-31 / IL31

    背景

    Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells (1,2). IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor (2). In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways (3). RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells . IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development (1,4).Synonyms: IL-31

    基因ID

    76399

    UniProt

    Q6EAL8
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