IKAP/p150 抗体 (C-Term)
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北京 101111
Quick Overview for IKAP/p150 抗体 (C-Term) (ABIN499964)
抗原
See all IKAP/p150 (ELP1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody reacts to IKAP.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- IKAP antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human IKAP.
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亚型
- IgG
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anti-Elongator Complex Protein 1 (ELP1) (AA 1107-1258) antibody
ELP1 适用: 人 WB, ELISA, IP, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Elongator Complex Protein 1 (ELP1) (AA 1242-1331) antibodyELP1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 6G9 unconjugated
anti-Elongator Complex Protein 1 (ELP1) (AA 1093-1332) antibodyELP1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Elongator Complex Protein 1 (ELP1) (C-Term) antibodyELP1 适用: 人, 小鼠 WB, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western Blot: 0.5 to 1 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- IKAP/p150 (ELP1) (Elongator Complex Protein 1 (ELP1))
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别名
- ELP1 / IKBKAP
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背景
- IKAP was initially identified as a scaffold protein of the IkappaB kinase complex that could bind to IKKalpha, IKKbeta, NF-kappaB, and the NF-kappaB-inducing kinase (NIK), although later evidence has cast doubt on this. More recent reports show that mutations in IKAP such as a frameshift leading to a truncated protein or a missense mutation that leads to defective phosphorylation are responsible for the autosomal recessive genetic disease familial dysautonomia (FD). Reports indicating that it forms part of the RNA polymerase II transcription elongation complex suggest that this disease may be due to compromised transcription elongation. More recently, it was shown that IKAP associates with c-Jun N-terminal kinase (JNK) and could specifically enhance JNK activation induced by the upstream JNK activators MEKK1 and ASK1, indicating another possible cause for FD. At least two isoforms of IKAP are known two exist.Synonyms: Elongator complex protein 1, IKAP, IKK complex-associated protein, IkappaB kinase complex-associated protein, p150
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基因ID
- 8518
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UniProt
- O95163
抗原
-
