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HAAO 抗体 (N-Term)

HAAO 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN499940
发货至: 中国
  • 抗原 See all HAAO 抗体
    HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))
    抗原表位
    • 15
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 20
    • 12
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 26
    • 1
    克隆类型
    • 26
    • 1
    多克隆
    标记
    • 9
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HAAO antibody is un-conjugated
    应用范围
    • 22
    • 13
    • 13
    • 11
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    纯化方法
    Affinity chromatography purified via peptide column
    免疫原
    HAAO antibody was raised against a 17 amino acid peptide near the amino terminus of human HAAO.
    亚型
    IgG
    Top Product
    Discover our top product HAAO Primary Antibody
  • 应用备注
    ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 缓冲液
    PBS containing 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store the antibody undiluted at 2-8 °C.
  • 抗原
    HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))
    别名
    HAAO (HAAO 产品)
    别名
    Afu2g17450 antibody, 0610007K21Rik antibody, 0610012J07Rik antibody, 3-HAO antibody, 3-HAOxase antibody, 3HAO antibody, zgc:103585 antibody, HAO antibody, 3-hydroxyanthranilate 3,4-dioxygenase antibody, 3-hydroxyanthranilate 3,4-dioxygenase L homeolog antibody, SPO1774 antibody, CNB05620 antibody, AFUA_2G17450 antibody, Bcep18194_C7641 antibody, Kfla_5491 antibody, Micau_4935 antibody, RBRH_03005 antibody, Krodi_1278 antibody, haao antibody, HAAO antibody, Haao antibody, haao.L antibody
    背景
    HAAO (3-Hydroxyanthranilate 3,4-dioxygenase) is a monomeric cytosolic protein of the family of intramolecular dioxygenases containing non-heme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is present in low amounts in the central nervous system. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurological and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. Furthermore, recent study shows that HAAO are excellent candidate biomarkers for detecting ovarian cancer.Synonyms: 3-HAO, 3-hydroxyanthranilate 3, 3-hydroxyanthranilate oxygenase, 3-hydroxyanthranilic acid dioxygenase, 4-dioxygenase, HAD
    基因ID
    23498
    NCBI登录号
    NP_036337
    UniProt
    P46952
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