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GOLPH3 抗体 (N-Term)

GOLPH3 适用: 人, 小鼠, 大鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN499904
发货至: 中国
  • 抗原 See all GOLPH3 抗体
    GOLPH3 (Golgi phosphoprotein 3 (Coat-Protein) (GOLPH3))
    抗原表位
    • 15
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 44
    • 13
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 39
    • 4
    • 1
    克隆类型
    • 42
    • 2
    多克隆
    标记
    • 26
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GOLPH3 antibody is un-conjugated
    应用范围
    • 39
    • 13
    • 13
    • 13
    • 10
    • 7
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    纯化方法
    Affinity chromatography purified via peptide column
    免疫原
    GOLPH3 antibody was raised against a 14 amino acid peptide from near the amino terminus of human GOLPH3.
    亚型
    IgG
    Top Product
    Discover our top product GOLPH3 Primary Antibody
  • 应用备注
    ELISA. Western Blot: 0.5 - 1 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS containing 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Store the antibody (in aliquots) at -20 °C.
  • 抗原
    GOLPH3 (Golgi phosphoprotein 3 (Coat-Protein) (GOLPH3))
    别名
    Golgi Phosphoprotein 3 / GOLPH3 (GOLPH3 产品)
    别名
    wu:fj66a10 antibody, zgc:101573 antibody, zgc:110223 antibody, 4733401N08Rik antibody, 5730410D03Rik antibody, AW413496 antibody, GOPP1 antibody, GPP34 antibody, MIDAS antibody, Gmx33 antibody, golgi phosphoprotein 3 antibody, golph3 antibody, CpipJ_CPIJ009278 antibody, Golph3 antibody, GOLPH3 antibody
    背景
    GOLPH3 was initially identified as a peripheral membrane protein localized to the trans-Golgi network, but others reported it to be primarily a mitochondrial protein that regulated the mitochondrial mass through the regulation of the mitochondria-specific phospholipid cardiolipin. GOLPH3 has since been implicated in the target of rapamycin (TOR) signalling pathway. Its overexpression in transfected cells led to and increase in anchorage-independent growth and cell proliferation in vitro. Furthermore, GOLPH3-transfected cells enhanced S6 Kinase activity in response to growth factor stimulation by EGF. Simultaneously, AKT phosphorylation increased in these cells, while these events were abrogated in GOLPH3 siRNA treated cells compared to control cells, indicating the GOLPH3 can enhance signalling through TOR-associated complexes. These results suggest that GOLPH3 is a bona fide oncogene and may be a useful target for therapeutic strategies.Synonyms: Coat protein GPP34, GPP34, MIDAS, Mitochondrial DNA absence factor
    基因ID
    64083
    UniProt
    Q9H4A6
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