FRMPD1 抗体 (C-Term)
This 兔 多克隆 anti-FRMPD1 antibody specifically detects FRMPD1 in WB, IF 和 EIA. The antibody is reactive with 人 samples.
产品编号 ABIN499857
发货至:
中国
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Quick Overview for FRMPD1 抗体 (C-Term) (ABIN499857)
抗原
See all FRMPD1 抗体
FRMPD1
(FERM and PDZ Domain Containing 1 (FRMPD1))
适用
人
宿主
兔
克隆类型
多克隆
标记
This FRMPD1 antibody is un-conjugated
应用范围
Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
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抗原表位
- C-Term
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- FRMPD1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human FRMPD1.
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亚型
- IgG
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anti-FERM and PDZ Domain Containing 1 (FRMPD1) (AA 1-1578) antibody
FRMPD1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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ELISA. Western Blot: 1 - 2 μg/mL. Immunofluorescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store the antibody (in aliquots) at -20 °C.
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- FRMPD1 (FERM and PDZ Domain Containing 1 (FRMPD1))
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别名
- FRMPD1
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背景
- The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD1 was initially identified through a yeast two-hybrid screening with Activator of G-protein signaling 3 (AGS3), a protein that acts to stabilize the GDP-bound conformation of Gai, as the bait. FRMPD1 binds to the tetratricopeptide repeat of AGS3 and stabilizes AGS3 in a membrane environment. Suppression of FRMPD1 in Cath.a-differentiated neuronal cells decreased the level of endogenous AGS3 in membrane fractions by ~50 % and enhanced the inhibition of forskolin-induced increases in cAMP. Co-immunoprecipitation studies indicate that the interaction of AGS3 with FRMPD1 is mutually exclusive with the interaction of AGS3 with Gai3, suggesting that FRMPD1 may position AGS3 in the membrane where it can then interact with Galphai.Synonyms: FERM and PDZ domain-containing protein 1, FERM domain-containing protein 2, FRMD2, KIAA0967
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基因ID
- 22844
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NCBI登录号
- NP_055722
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UniProt
- Q5SYB0
抗原
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