TMC8 抗体 (Center)
Quick Overview for TMC8 抗体 (Center) (ABIN499810)
抗原
See all TMC8 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Center
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特异性
- This antibody reacts to EVER2.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- EVER2 antibody was raised against a 14 amino acid peptide from near the center of human EVER2.
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亚型
- IgG
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anti-Transmembrane Channel-Like 8 (TMC8) (C-Term) antibody
TMC8 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Channel-Like 8 (TMC8) (C-Term) antibodyTMC8 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Channel-Like 8 (TMC8) (C-Term) antibodyTMC8 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Channel-Like 8 (TMC8) (AA 143-192) antibodyTMC8 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western Blt: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- TMC8 (Transmembrane Channel-Like 8 (TMC8))
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别名
- TMC8
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背景
- Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis associated with a high risk of skin cancers resulting from a high susceptibility to infection by specific human papillomaviruses. Mutations in two homologous genes EVER1 and EVER2 cause the majority of EV cases. These two proteins form a complex and interact with the zinc transporter ZnT-1 in the endoplasmic reticulum. Cells lacking EVER2 accumulated higher levels of zinc in the nucleolus and nucleus compare to those cells with and intact EVER2 gene, indicating that one role of EVER2 is to regulate the intracellular distribution of zinc. At least three isoforms of EVER2 are known to exist, this antibody will only recognize the larger isoform. EVER2 has no cross-reactivity to EVER1.Synonyms: EVER2, EVIN2, Epidermodysplasia verruciformis protein 2, Transmembrane channel-like protein 8
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基因ID
- 147138
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UniProt
- Q8IU68
抗原
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