EBI3 抗体 (Center)
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北京 101111
Quick Overview for EBI3 抗体 (Center) (ABIN499778)
抗原
See all EBI3 (IL-27b) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Center
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特异性
- This antibody reacts to EBI3.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- EBI3 antibody was raised against a 16 amino acid peptide from near the center of human EBI3.
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亚型
- IgG
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anti-Interleukin-27 subunit beta (IL-27b) (AA 21-229) antibody
IL-27b 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal 2-3# unconjugated
anti-Interleukin-27 subunit beta (IL-27b) antibodyIL-27b 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Interleukin-27 subunit beta (IL-27b) antibodyIL-27b 适用: 小鼠 ELISA, IP, Neut 宿主: 小鼠 Monoclonal V1-4C4-22 unconjugated
anti-Interleukin-27 subunit beta (IL-27b) (AA 21-227) antibodyIL-27b 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin-27 subunit beta (IL-27b) (AA 21-229) antibodyIL-27b 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin-27 subunit beta (IL-27b) (AA 153-181), (C-Term) antibodyIL-27b 适用: 人 WB 宿主: 兔 Polyclonal RB30602 unconjugated
anti-Interleukin-27 subunit beta (IL-27b) (AA 129-229) antibodyIL-27b 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Interleukin-27 subunit beta (IL-27b) (C-Term) antibodyIL-27b 适用: 人, 小鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin-27 subunit beta (IL-27b) (AA 21-229) antibodyIL-27b 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal 1-1# unconjugated
anti-Interleukin-27 subunit beta (IL-27b) (AA 1-229) antibodyIL-27b 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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ELISA. Western Blot: 2 - 4 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- EBI3 (IL-27b) (Interleukin-27 subunit beta (IL-27b))
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别名
- EBI3 / IL27B
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背景
- EBI3 is a subunit in two distinct heterodimeric cytokines: interleukin-27 (IL-27) and IL-35 (1-3). Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naive but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 (also known as TCCR) and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-g, and T-bet. IL-35 is composed of EBI3 and the p35 subunit of IL-12 and has been reported to have therapeutic effects against collagen-induced arthritis by expanding the population of regulatory T cells and suppressing Th17 cells. At least two isoform of EBI3 are known to exist.Synonyms: EBV-induced gene 3 protein, Epstein-Barr virus-induced gene 3 protein, IL-27 subunit beta, IL-27B, Interleukin-27 subunit beta
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基因ID
- 10148
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NCBI登录号
- NP_005746
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UniProt
- Q14213
抗原
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