DEDD2 抗体
Quick Overview for DEDD2 抗体 (ABIN499734)
抗原
See all DEDD2 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- DEDD2 antibody was raised against a peptide corresponding to 11 amino acids near the amino-terminus of human DEDD2.
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纯化方法
- Immunoaffinity chromatography purified IgG
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免疫原
- Human DEDD2 Peptide
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亚型
- IgG
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anti-Death Effector Domain Containing 2 (DEDD2) (AA 1-240) antibody
DEDD2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Death Effector Domain Containing 2 (DEDD2) (AA 162-193) antibodyDEDD2 适用: 人 WB 宿主: 兔 Polyclonal RB53921 unconjugated
anti-Death Effector Domain Containing 2 (DEDD2) (AA 43-75) antibodyDEDD2 适用: 人 WB 宿主: 兔 Polyclonal RB54369 unconjugated
anti-Death Effector Domain Containing 2 (DEDD2) (AA 179-228) antibodyDEDD2 适用: 人, 小鼠, 兔, Cow, 犬, 豚鼠, 马, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Death Effector Domain Containing 2 (DEDD2) (Middle Region) antibodyDEDD2 适用: 人, 大鼠, 小鼠, 兔, Cow, 犬, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western Blot: 0.5 to 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- DEDD2 (Death Effector Domain Containing 2 (DEDD2))
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别名
- DEDD2
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背景
- Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain (1). A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified and its over-expression in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD (2). More recently, work has shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD (2,3). Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis (3). At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.Synonyms: DED-containing protein FLAME-3, DEDD-2, DNA-binding death effector domain-containing protein 2, FADD-like anti-apoptotic molecule 3, FLAME-3, FLAME3, PSEC0004
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基因ID
- 162989
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NCBI登录号
- NP_579874
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UniProt
- Q8WXF8
抗原
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