DAD1 抗体
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北京 101111
Quick Overview for DAD1 抗体 (ABIN499706)
抗原
See all DAD1 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- DAD1 antibody was raised against a peptide corresponding to 14 amino acids near the C-terminus of human DAD1.
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纯化方法
- Ion exchange chromatography
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免疫原
- Murine DAD1 Peptide
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亚型
- IgG
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anti-Defender Against Cell Death 1 (DAD1) (C-Term) antibody
DAD1 适用: 人, 小鼠 WB, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Defender Against Cell Death 1 (DAD1) (AA 1-113) antibodyDAD1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Defender Against Cell Death 1 (DAD1) (AA 1-100) antibodyDAD1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Defender Against Cell Death 1 (DAD1) (AA 1-113) antibodyDAD1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2B4-C8 unconjugated
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应用备注
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ELISA. Western Blot: 0.5 to 2 μg/mL. Despite its predicted molecular weight, DAD1 migrates at approx. 22 kDa in SDS-PAGE. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- DAD1 (Defender Against Cell Death 1 (DAD1))
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别名
- DAD1
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背景
- Defender of cell death 1 (DAD1) was initially discovered in BHK21 cells as a negative regulator of programmed cell death (1), a process important for normal organism development and tissue homeostasis (2). DAD1 was later shown to be a subunit of the mammalian oligosaccharyltransferase complex and is required for its function and structural integrity (3,4). Mice lacking DAD1 express abnormal N-linked glycoproteins and undergo increased apoptotic-associated embryonic death (5,6). Furthermore, overexpression of DAD1 mRNA is seen in some human hepatocellular carcinomas (7), indicating it may also play a role in carcinogenesis. It should be noted that DAD1 is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.Synonyms: DAD-1, OST2, defender against cell death 1, dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit DAD1, oligosaccharyl transferase subunit DAD1
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基因ID
- 1603
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UniProt
- P61803
抗原
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