CNOT4 抗体 (N-Term)
Quick Overview for CNOT4 抗体 (N-Term) (ABIN499646)
抗原
See all CNOT4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- This antibody reacts to CNOT4.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- CNOT4 antibody was raised against a 19 amino acid peptide near the amino terminus of the human CNOT4.
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亚型
- IgG
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anti-CCR4-NOT Transcription Complex Subunit 4 (CNOT4) (AA 190-455) antibody
CNOT4 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1H2 unconjugated
anti-CCR4-NOT Transcription Complex Subunit 4 (CNOT4) (N-Term) antibodyCNOT4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-CCR4-NOT Transcription Complex Subunit 4 (CNOT4) (AA 50-100) antibodyCNOT4 适用: 人, 小鼠, 大鼠, Cow, 小鸡, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CCR4-NOT Transcription Complex Subunit 4 (CNOT4) antibodyCNOT4 适用: 人, 小鼠 WB 宿主: 小鼠 Monoclonal 3C5 unconjugated
anti-CCR4-NOT Transcription Complex Subunit 4 (CNOT4) (AA 539-588) antibodyCNOT4 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 斑马鱼, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-CCR4-NOT Transcription Complex Subunit 4 (CNOT4) (Middle Region) antibodyCNOT4 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 斑马鱼, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-CCR4-NOT Transcription Complex Subunit 4 (CNOT4) (AA 61-110) antibodyCNOT4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western Blot: CNOT4 antibody can be used for detection of CNOT4 at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- CNOT4 (CCR4-NOT Transcription Complex Subunit 4 (CNOT4))
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别名
- CNOT4
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背景
- CNOT4 is a component of the CCR4-NOT transcription complex, a complex that is implicated in the repression of RNA polymerase II transcription. In the CCR4-NOT complex, CNOT4 acts as an E3 ubiquitin-protein ligase and interacts with a subset of E2 ubiquitin-conjugating enzymes through a unique C4C4 RING domain. This E3 ligase activity was shown to be dependent on the selective and specific interaction with the ubiquitin conjugating enzyme UbcH5B. In yeast, mutations in CNOT4 that prevented its interaction with the UbcH5B homolog UBC4 caused increased sensitivity to hydroxyurea, heat shock, and hygromycin B, suggesting that CNOT4 and UbcH5B are involved in stress response in vivo. Multiple isoforms of CNOT4 are known to exist.Synonyms: CCR4-NOT transcription complex subunit 4, CCR4-associated factor 4, E3 ubiquitin-protein ligase CNOT4, NOT4, NOT4Hp, Potential transcriptional repressor NOT4Hp
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基因ID
- 4850
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NCBI登录号
- NP_037448
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UniProt
- O95628
抗原
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