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Acetyl-CoA Carboxylase alpha 抗体 (AbBy Fluor® 750)

The AbBy Fluor® 750-conjugated 兔 多克隆 anti-Acetyl-CoA Carboxylase alpha antibody (ABIN4995920) specifically detects Acetyl-CoA Carboxylase alpha in WB 和 IF (p). The antibody is reactive with 人, 小鼠 和 大鼠 samples.
产品编号 ABIN4995920
发货至: 中国
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Quick Overview for Acetyl-CoA Carboxylase alpha 抗体 (AbBy Fluor® 750) (ABIN4995920)

抗原

See all Acetyl-CoA Carboxylase alpha (ACACA) 抗体
Acetyl-CoA Carboxylase alpha (ACACA)

适用

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  • 1
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人, 小鼠, 大鼠

宿主

  • 99
  • 5
  • 1

克隆类型

  • 91
  • 14
多克隆

标记

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  • 2
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  • 2
  • 2
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  • 1
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This Acetyl-CoA Carboxylase alpha antibody is conjugated to AbBy Fluor® 750

应用范围

  • 92
  • 37
  • 30
  • 26
  • 14
  • 14
  • 11
  • 9
  • 9
  • 3
  • 3
  • 1
Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • 交叉反应

    人, 小鼠, 大鼠

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human ACACA

    亚型

    IgG
  • 应用备注

    IF(IHC-P)(1:50-200)

    限制

    仅限研究用
  • 浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    Acetyl-CoA Carboxylase alpha (ACACA)

    别名

    ACACA

    背景

    Synonyms: ACAC, ACACA, ACACA, ACACA_HUMAN, ACC alpha, ACC-alpha, ACC1, ACC1, ACCA, Acetyl Coenzyme A, Biotin carboxylase, ACACA_MOUSE, Acetyl Coenzyme A carboxylase alpha, ACACA_RAT.

    Background: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACC alpha (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACCâ^ (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACC alpha is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the enzyme’s short-term regulatory mechanism. The gene encoding ACC alpha maps to human chromosome 17 and encodes a form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACCâ^ is homologous to that of the ACCå, except for an additional peptide of about 150 amino acids at the N-terminus.

    途径

    AMPK Signaling, Ribonucleoside Biosynthetic Process, Warburg Effect
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