Carabin 抗体 (C-Term)
Quick Overview for Carabin 抗体 (C-Term) (ABIN499529)
抗原
See all Carabin (TBC1D10C) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody reacts to Carabin.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- Carabin antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human Carabin.
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亚型
- IgG
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anti-TBC1 Domain Family, Member 10C (TBC1D10C) (Internal Region) antibody
Verified TBC1D10C 适用: 人, 小鼠 WB, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 10C (TBC1D10C) (N-Term) antibodyTBC1D10C 适用: 人, Cow, 大鼠, 犬, 豚鼠, 马, 猴, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 10C (TBC1D10C) (N-Term) antibodyTBC1D10C 适用: 人, Cow, 大鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 10C (TBC1D10C) (AA 14-236) antibodyTBC1D10C 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 10C (TBC1D10C) (N-Term) antibodyTBC1D10C 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 10C (TBC1D10C) (N-Term) antibodyTBC1D10C 适用: 人, Cow, 大鼠, 犬, 豚鼠, 马, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western Blot: Carabin antibody can be used for detection of Carabin at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- Carabin (TBC1D10C) (TBC1 Domain Family, Member 10C (TBC1D10C))
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别名
- Carabin
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背景
- Antigen binding by the T-cell receptor (TCR) is one of the critical first steps in the immune response, triggering a cascade of signaling pathways that ultimately lead to T-cell activation. Screening a yeast two-hybrid screen of a human T-cell cDNA library with calcineurin, a protein phosphatase involved in multiple signaling pathways including T-cell activation, resulted in the identification of Carabin, a member of the TBC1 domain family of proteins, as a calcineurin-binding protein. Unlike other members of the TBC1 domain protein family which are thought to have a role in regulating cell growth and differentiation, further experiments demonstrated that Carabin is part of a negative regulatory loop for the intracellular TCR signaling pathway as well as an inhibitor of the Ras signaling pathway, suggesting that Carabin may also mediate crosstalk between calcineurin and Ras. Carabin antibody does not recognize TBC1D10A or TBC1D10B. Carabin is known to exist in multiple isoforms.Synonyms: TBC1 domain family member 10C, TBC1D10C
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基因ID
- 374403
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NCBI登录号
- NP_940919
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UniProt
- Q8IV04
抗原
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