BORA 抗体 (C-Term)
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北京 101111
Quick Overview for BORA 抗体 (C-Term) (ABIN499489)
抗原
See all BORA 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody reacts to Bora.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- Bora antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human Bora.
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亚型
- IgG
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anti-Protein Aurora Borealis (BORA) (AA 178-312) antibody
BORA 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Aurora Borealis (BORA) antibodyBORA 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB6875 unconjugated Recombinant Antibody
anti-Protein Aurora Borealis (BORA) (C-Term) antibodyBORA 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Aurora Borealis (BORA) (N-Term) antibodyBORA 适用: 人, 大鼠, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western Blot: Bora antibody can be used for detection of Bora at 1-2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- BORA (Protein Aurora Borealis (BORA))
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别名
- Protein Aurora Borealis
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背景
- Bora (Protein aurora borealis) is a key activator of Aurora Related Protein Kinase A (ARK-1), which is a centrosome-associated serine/threonine kinase that regulates centrosome maturation, bipolar spindle assembly and chromosome segregation during mitosis. Bora is localized to the nucleus until mitosis is initiated, then translocates to the cytoplasm in a Cdc2 dependent manner. Activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate ARK-1. PLK1 (polo-like kinase-1) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation by ARK-1. Bora and ARK-1 cooperatively activate PLK1 and control mitotic entry. Bora mutants result in multipolar spindles in mitosis identical to those observed when ARK-1 function is blocked. Thus, the ARK1-Bora-PLK1 regulatory circuit in mammalian cells elucidates a key mechanism in cell cycle regulation. At least three isoforms of Bora are known to exist.Synonyms: BORA, C13orf34, FLJ22624, HsBora
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基因ID
- 79866
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UniProt
- Q6PGQ7
抗原
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