BMF 抗体 (N-Term)
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北京 101111
Quick Overview for BMF 抗体 (N-Term) (ABIN499481)
抗原
See all BMF 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- EndoG antibody was raised with a synthetic peptide corresponding to 15 amino acids near the amino terminus of human EndoG.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- Human Bmf (N-Terminus) Peptide
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亚型
- IgG
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anti-Bcl2 Modifying Factor (BMF) (AA 1-181) antibody
BMF 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Bcl2 Modifying Factor (BMF) (AA 112-126), (AA 13-27) antibodyBMF 适用: 小鼠, 大鼠 WB, IHC, ELISA, FACS, IP, ICC 宿主: 大鼠 Monoclonal 17A9 unconjugated
anti-Bcl2 Modifying Factor (BMF) (AA 1-184) antibodyBMF 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Bcl2 Modifying Factor (BMF) (AA 115-150) antibodyBMF 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB00594 unconjugated
anti-Bcl2 Modifying Factor (BMF) (BH3 Domain) antibodyBMF 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Bcl2 Modifying Factor (BMF) (AA 130-150), (BH3 Domain) antibodyBMF 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western Blot: Bmf antibody can be used for detection of Bmf at 2 μg/mL. HepG2 or 293 celllysate can be used as a positive control and a band at approximately 25 kDa can bedetected. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- BMF (Bcl2 Modifying Factor (BMF))
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别名
- BMF
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背景
- Apoptosis is related to many diseases and development. Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3-only proteins, including Bad, Bid, Bik, Hrk, Bim, Noxa, and PUMA, form a growing subclass of the Bcl-2 family. A novel BH3-only protein was recently identified in human and mouse and designated Bmf (for Bcl-2-modifing factor) (1). The BH3 domain in Bmf is required both for binding to Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf associates with the dynein light chain 2 (DLC2) component of the myosin V motors and is sequestered by the cell's actin cytoskeleton. Disruption of the actin cytoskeleton, either by depolymerization of actin filaments or by detachment of cells from the extracellular matrix, triggers release and activation of Bmf, initiating the downstream apoptotic program (1,2). Bmf is constitutively expressed in many tissues (1,2).Synonyms: Bcl-2-modifying factor
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基因ID
- 90427
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NCBI登录号
- NP_277038
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UniProt
- Q96LC9
抗原
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