BCL2L13 抗体 (Intermediate Domain)
Quick Overview for BCL2L13 抗体 (Intermediate Domain) (ABIN499433)
抗原
See all BCL2L13 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Intermediate Domain
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特异性
- Bcl-rambo antibody was raised against a 15 amino acid peptide from near the center of human Bcl-rambo.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- Human Bcl-rambo / Bcl-2 like protein 13 / Mil1 (Intermediate Domain) Peptide
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亚型
- IgG
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anti-BCL2-Like 13 (Apoptosis Facilitator) (BCL2L13) (AA 1-300) antibody
BCL2L13 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Like 13 (Apoptosis Facilitator) (BCL2L13) (AA 1-485) antibodyBCL2L13 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4G11 unconjugated
anti-BCL2-Like 13 (Apoptosis Facilitator) (BCL2L13) (AA 395-444) antibodyBCL2L13 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Like 13 (Apoptosis Facilitator) (BCL2L13) (AA 342-369), (C-Term) antibodyBCL2L13 适用: 人 WB 宿主: 兔 Polyclonal RB16891 unconjugated
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应用备注
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ELISA. Western Blot: Bcl-rambo antibody can be used for the detection of Bcl-rambo at 2 μg/mL. K562 cell lysate can be used as positive control. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- BCL2L13 (BCL2-Like 13 (Apoptosis Facilitator) (BCL2L13))
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背景
- Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains (reviewed in 2 and 3). A novel, widely expressed member termed Bcl-rambo was recently identified. This protein is localized to mitochondria in mammalian cells and its overexpression induces apoptosis which could be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2 (4). Bcl-rambo shows overall homology to the anti-apoptotic members containing BH motifs, but unlike Bcl-2, the C-terminal membrane anchor of Bcl-rambo is preceded by a unique 250 amino acid insertion. This region by itself can induce apoptosis more efficiently than the Bcl-2 homology regions, suggesting that Bcl-rambo may be important other pro-apoptotic pathways (4).Synonyms: BCL2L13, Bcl-2-like protein 13, Bcl-rambo, Bcl2-L-13, CD003, MIL1
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基因ID
- 23786
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UniProt
- Q9BXK5
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途径
- Positive Regulation of Endopeptidase Activity
抗原
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