ANTXR1 抗体 (C-Term)
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北京 101111
Quick Overview for ANTXR1 抗体 (C-Term) (ABIN499365)
抗原
See all ANTXR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- ATR antibody was raised against a peptide corresponding to 13 amino acids near the C-terminus of human ATR. ATR will recognize only the largest isoform.
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纯化方法
- Ion exchange chromatography
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免疫原
- Human ATR / TEM8 (C-Terminus) Peptide
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亚型
- IgG
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anti-anthrax Toxin Receptor 1 (ANTXR1) (C-Term) antibody
Verified ANTXR1 适用: 人 ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-anthrax Toxin Receptor 1 (ANTXR1) (Internal Region) antibodyANTXR1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-anthrax Toxin Receptor 1 (ANTXR1) (AA 315-564) antibodyANTXR1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-anthrax Toxin Receptor 1 (ANTXR1) (AA 481-497) antibodyANTXR1 适用: 人, 犬, 兔, 猴 WB 宿主: 小鼠 Monoclonal 200C1339(SB20) unconjugated
anti-anthrax Toxin Receptor 1 (ANTXR1) (AA 396-445) antibodyANTXR1 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 豚鼠, 马, 猴, Bat, 小鸡, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-anthrax Toxin Receptor 1 (ANTXR1) (C-Term) antibodyANTXR1 适用: 人, 小鼠, 大鼠 WB, ICC 宿主: 兔 Polyclonal unconjugated
anti-anthrax Toxin Receptor 1 (ANTXR1) (AA 358-386) antibodyANTXR1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB15324 unconjugated
anti-anthrax Toxin Receptor 1 (ANTXR1) (Intermediate Domain) antibodyANTXR1 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-anthrax Toxin Receptor 1 (ANTXR1) (AA 365-394), (Tyr382) antibodyANTXR1 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western Blot: ATR antibody can be used for detection of ATR by Western blot at 1 to 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- ANTXR1 (anthrax Toxin Receptor 1 (ANTXR1))
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别名
- Anthrax Toxin Receptor 1
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背景
- The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8) (1). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin (2). Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF) (3). This complex is then endocytosed by the cell, acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis (4).Synonyms: ANTXR1, ATR, TEM8, Tumor endothelial marker 8
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基因ID
- 84168
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NCBI登录号
- NP_444262
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UniProt
- Q9H6X2
抗原
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