ASAH2 抗体 (C-Term)
Our Local Distributor
北京 101111
Quick Overview for ASAH2 抗体 (C-Term) (ABIN499341)
抗原
See all ASAH2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- C-Term
-
特异性
- This antibody reacts to ASAH2.
-
纯化方法
- Affinity chromatography purified via peptide column
-
免疫原
- ASAH2 antibody was raised against a 17 amino acid peptide near the carboxy terminus of the human ASAH2.
-
亚型
- IgG
-
-
anti-N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2 (ASAH2) (AA 255-506) antibody
ASAH2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2 (ASAH2) antibodyASAH2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2 (ASAH2) (C-Term) antibodyASAH2 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2 (ASAH2) (AA 80-340) antibodyASAH2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2 (ASAH2) antibodyASAH2 适用: 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2 (ASAH2) (AA 734-762) antibodyASAH2 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
ELISA. Western Blot: ASAH2 antibody can be used for detection of ASAH2 at 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
缓冲液
- PBS containing 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C
-
储存方法
- Store the antibody undiluted at 2-8 °C.
-
-
- ASAH2 (N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2 (ASAH2))
-
别名
- Neutral Ceramidase / ASAH2
-
背景
- Sphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids. These ceramidases are classified according to the pH range that supports their optimal activity. ASAH2 is a neutral ceramidase and key regulator of sphingolipid signaling metabolites at the cell surface, catalyzing the hydrolysis of the N-acyl linkage of ceramide at an optimal pH of 6.5-8.5. ASAH2 is a type II integral membrane protein that can be cleaved to yield a soluble secreted protein and acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger. ASAH2 is ubiquitously expressed primarily expressed with higher levels in the intestine, kidney, skeletal muscle and heart. Recent studies indicate that ASAH2 encoded neutral ceramidase is a key enzyme for the catabolism of dietary sphingolipids and regulates the levels of bioactive sphingolipid metabolites in the intestinal tract.Synonyms: Acylsphingosine deacylase 2, BCDase, HNAC1, LCDase, N-acylsphingosine amidohydrolase 2, Non-lysosomal ceramidase, hCD
-
基因ID
- 56624
-
NCBI登录号
- NP_063946
-
UniProt
- Q9NR71
抗原
-
