APOBEC3G 抗体 (N-Term)
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Quick Overview for APOBEC3G 抗体 (N-Term) (ABIN499313)
抗原
See all APOBEC3G 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- APOBEC3G antibody was raised against a synthetic peptide corresponding to 15 amino acids near the amino-terminus of human APOBEC3G antibody will also detect the APOBEC3F isoform.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- Human APOBEC3G (N-Terminus) Peptide
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亚型
- IgG
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应用备注
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ELISA. Western Blot: APOBEC3G antibody can be used for detection of APOBEC3G at 5 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- APOBEC3G (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G))
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别名
- APOBEC3G
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背景
- The Apoliprotein B mRNA-editing, enzyme-catalytic, polypeptide-like (APOBEC) 3 is a multi-isoform member of the cytidine deaminase family of enzymes that act on monomeric nucleoside and nucleotide substrates (1). Similar to TRIM5alpha which targets incoming retroviral capsids, APOBEC3 plays a major role in cellular defense against retroviral infection (2,3) as at least two isoforms, APOBEC3G and to a lesser extent APOBEC3F, can be incorporated HIV-1 virions and induce hypermutation in the newly synthesized viral DNA and thus destabilize the viral genome (4,5). This innate mechanism of retroviral resistance is counteracted by the HIV-1 Vif protein by inducing the ubiquitization and degradation of APOBEC3G, a single amino acid substitution (D128K) blocks APOBEC3G depletion without affecting its inhibitory activity (6).Synonyms: APOBEC-3G, APOBEC-related cytidine deaminase, ARCD, ARP9, CEM15, DNA dC->dU-editing enzyme APOBEC-3G, MDS019
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基因ID
- 60489
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NCBI登录号
- NP_068594
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UniProt
- Q9HC16
抗原
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