AIPL1 抗体 (Center)
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Quick Overview for AIPL1 抗体 (Center) (ABIN499251)
抗原
See all AIPL1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Center
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特异性
- This antibody reacts to AIPL1.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- Aipl1 antibody was raised against a 18 amino acid peptide near the center of the human Aipl1.
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亚型
- IgG
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应用备注
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ELISA. Western Blot: Aipl1 antibody can be used for detection of Aipl1 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- AIPL1 (Aryl Hydrocarbon Receptor Interacting Protein-Like 1 (AIPL1))
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别名
- AIPL1
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背景
- Aipl1 was initially identified as a protein implicated in Leber congenital amaurosis (LCA), an autosomal recessive disorder thought to be caused by the abnormal development of photoreceptors. Aipl1 is a tetratricopeptide repeat protein that is highly homologous to ARA9, a protein involved in the HSP90-mediated nuclear translocation and transactivation of the aryl hydrocarbon receptor. Aipl1 has also been found to function as part of a chaperone heterocomplex, interacting with Hsp90 and Hsp70. Aipl1 also associates with the cell cycle regulator NUB1. It is thought that Aipl1 cooperates with Hsp70 but not Hsp90 to suppress the formation of NUB1 inclusions, and these interactions are necessary in the normal photoreceptor maturation, as mutations that lead to LCA also compromise the interactions with the Hsp chaperones. At least three isoforms of Aipl1 are known to exist.Synonyms: Aryl-hydrocarbon-interacting protein-like 1
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基因ID
- 23746
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NCBI登录号
- NP_055151
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UniProt
- Q9NZN9
抗原
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