AFAP1L2 抗体 (C-Term)
Quick Overview for AFAP1L2 抗体 (C-Term) (ABIN499229)
抗原
See all AFAP1L2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This anitbody reacts to AFAP1L2.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- AFAP1L2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human AFAP1L2.
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亚型
- IgG
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anti-Actin Filament Associated Protein 1-Like 2 (AFAP1L2) (AA 674-818) antibody
AFAP1L2 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 2H6D1 unconjugated
anti-Actin Filament Associated Protein 1-Like 2 (AFAP1L2) (AA 66-115) antibodyAFAP1L2 适用: 人, 小鼠, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Actin Filament Associated Protein 1-Like 2 (AFAP1L2) (AA 1-300) antibodyAFAP1L2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Actin Filament Associated Protein 1-Like 2 (AFAP1L2) (N-Term) antibodyAFAP1L2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western Blot: AFAP1L2 antibody can be used for detection of AFAP1L2 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- AFAP1L2 (Actin Filament Associated Protein 1-Like 2 (AFAP1L2))
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别名
- AFAP1L2
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背景
- AFAP1L2, also known as XB130, is structurally similar to actin-filament-associated protein (AFAP), containing several SH2- and SH3-binding motifs, two pleckstrin homology domains, a coiled-coil region, and many potential phosphorylation sites. It interacts with and is phosphorylated by c-Src tyrosine kinase. Suppression of AFAP1L2 via siRNA reduced Src activity, IL-8 production, EGF-induced phosphorylation of Akt and GSK3b, and altered cell cycles in human lung epithelial cells suggesting that AFAP1L2 plays a role as an adaptor in the regulation of Src signal transduction and multiple cellular functions. Recent experiments have shown that AFAP1L2 is highly expressed in thyroid and is the substrate RET/PTC kinase, a thyroid-specific kinase that plays a pathogenic role in papillary thyroid cancer. Down-regulation of AFAP1L2 in these cancer cells reduced Akt activity, inhibiting cell-cycle progression and cancer cell survival in suspension, indicating that AFAP1L2 may be a valuable target in thyroid cancer therapy. At least four isoforms of AFAP1L2 are known to exist.Synonyms: AFAP1-like protein 2, Actin filament-associated protein 1-like 2, KIAA1914, XB130
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基因ID
- 84632
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NCBI登录号
- NP_001001936
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UniProt
- Q8N4X5
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途径
- EGFR Signaling Pathway
抗原
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