TNIP3 抗体 (C-Term)
The 兔 多克隆 anti-TNIP3 antibody is suitable to detect TNIP3 in samples from 人 和 小鼠. It has been validated for WB, IHC (p) 和 EIA.
产品编号 ABIN499187
发货至:
中国
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Quick Overview for TNIP3 抗体 (C-Term) (ABIN499187)
抗原
See all TNIP3 抗体
TNIP3
(TNFAIP3 Interacting Protein 3 (TNIP3))
适用
人, 小鼠
宿主
兔
克隆类型
多克隆
标记
This TNIP3 antibody is un-conjugated
应用范围
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
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抗原表位
- C-Term
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特异性
- This antibody reactcs to ABIN3 near the carboxy terminus.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- ABIN3 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human ABIN3.
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亚型
- IgG
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anti-TNFAIP3 Interacting Protein 3 (TNIP3) (AA 74-102), (N-Term) antibody
TNIP3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB27057 unconjugated
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应用备注
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ELISA. Western Blot: ABIN3 antibody can be used for detection of ABIN3 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- TNIP3 (TNFAIP3 Interacting Protein 3 (TNIP3))
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别名
- TNIP3
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背景
- The nuclear factor NF-kB plays key roles in development and immunity. ABIN3 (A20-binding inhibitor of NF-kB activation 3), also known as TNFAIP3-interacting protein 3 (TNIP3), is a novel negative feedback regulator of LPS-induced NF-kB activation. ABIN3 is a 39 kDa protein that negatively regulates NF-kB activation in response to TNF and LPS. ABIN3 is highly expressed in brain, thymus, lymph node, lung and fetal liver, with low expression in kidney, bone marrow. Through its interaction with A20, ABIN3 interferes with TRAF2-mediated transactivation signals and NF-kB inhibition is mediated by the ABIN-homology domain 2. ABIN3 has been found to be induced by Listeria infection and can be slightly downregulated by dexamethasone. Enhanced expression of ABIN3 in monocytes is associated with sepsis. Thus, ABIN3 is an IL-10-induced gene product capable of attenuating NF-kB in human macrophages yet is inoperative in mice and represents a basis for species-specific differences in IL-10 actions. At least four isoforms of ABIN3 are known to exist.Synonyms: A20-binding inhibitor of NF-kappa-B activation 3, ABIN-3, ABIN3, LIND, Listeria-induced gene protein, TNFAIP3-interacting protein 3
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基因ID
- 79931
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NCBI登录号
- NP_079149
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UniProt
- Q96KP6
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途径
- Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin
抗原
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