AAK1 抗体 (C-Term)
Quick Overview for AAK1 抗体 (C-Term) (ABIN499181)
抗原
See all AAK1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- C-Term
-
特异性
- This antibody reacts to AAK1 near the carboxy terminus.
-
纯化方法
- Affinity chromatography purified via peptide column
-
免疫原
- Aak1 antibody was raised against a 18 amino acid peptide near the carboxy terminus of the human Aak1.
-
亚型
- IgG
-
-
anti-AP2 associated kinase 1 (AAK1) (AA 315-415) antibody
AAK1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4B10 unconjugated
anti-AP2 associated kinase 1 (AAK1) (AA 274-465) antibodyAAK1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-AP2 associated kinase 1 (AAK1) (N-Term) antibodyAAK1 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-AP2 associated kinase 1 (AAK1) (C-Term) antibodyAAK1 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-AP2 associated kinase 1 (AAK1) (AA 301-400) antibodyAAK1 适用: 小鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-AP2 associated kinase 1 (AAK1) (N-Term) antibodyAAK1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-AP2 associated kinase 1 (AAK1) antibodyAAK1 适用: 人, 小鼠, 大鼠, Cow WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-AP2 associated kinase 1 (AAK1) (Internal Region) antibodyVerified AAK1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-AP2 associated kinase 1 (AAK1) (AA 593-642) antibodyAAK1 适用: 人, 小鼠, 大鼠, 马, 兔, 猴, 犬, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-AP2 associated kinase 1 (AAK1) (Internal Region) antibodyAAK1 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
ELISA. Western Blot: Aak1 antibody can be used for detection of Aak1 at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
缓冲液
- PBS containing 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C
-
储存方法
- Store the antibody undiluted at 2-8 °C.
-
-
- AAK1 (AP2 associated kinase 1 (AAK1))
-
别名
- AAK1
-
背景
- AP2-associated protein kinase 1 (Aak1) is a member of the Ark1/Prk1 subfamily of Ser/Thr protein kinases that are thought to regulate endocytosis by phosphorylating the accessory endocytic components. Aak1 interacts with and phosphorylates the mu2 subunit of the AP-2 complex, which promotes binding of the AP-2 to tyrosine based (Yxxf) internalization motif-containing receptors and subsequent receptor endocytosis. At least two isoforms of Aak1 are known to exist, the longer isoform contains an extended carboxy-terminus that contains an additional clathrin-binding domain. Overexpression of this long isoform or Aak1 depletion by RNA interference impairs transferrin recycling from the early/sorting endosome, suggesting that Aak1 functions at multiple steps of the endosomal pathway by regulating transferrin internalization and its recycling back to the plasma membrane.Synonyms: AP2-associated protein kinase 1, KIAA1048
-
基因ID
- 22848
-
NCBI登录号
- NP_055726
-
UniProt
- Q2M2I8
抗原
-
