HOXA1 抗体
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Quick Overview for HOXA1 抗体 (ABIN499123)
抗原
See all HOXA1 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody is expected to recognize reported isoforms a and b (NP_005513.1 and, NP_705873.2).
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交叉反应 (详细)
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Species reactivity (expected):Mouse, Rat, Canine, Bovine.
Species reactivity (tested):Human. -
纯化方法
- Affinity Purified
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
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- HOXA1 (Homeobox A1 (HOXA1))
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别名
- HOXA1 / HOX1F
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背景
- Hox genes play a fundamental role in the development of the vertebrate central nervous system, heart, axial skeleton, limbs, gut, urogenital tract and external genitalia. The homeobox gene HoxA1 is transcriptionally regulated by retinoic acid (RA) and encodes a transcription factor which has been shown to play important roles in cell differentiation and embryogenesis. HoxA1 is also expressed in cancers, such as mammary tumors, though it is not expressed in normal gland or in precancerous mammary tissues. At embryonic stages, HoxA2 is expressed in the mesenchyme and epithelial cells of the palate, however its expression is restricted to the tips of the growing palatal shelves. HoxA2 protein is predominantly expressed in the nuclei of cells in the ventral mantle region of the developing embryo. In the developing and adult mouse spinal cord, HoxA2 protein may contribute to dorsal-ventral patterning and/or to the specification of neuronal phenotype. HoxA7 functions as a potent transcriptional repressor and its action as such requires several domains, including both activator and repressor regions. HoxA7 is expressed in the fetal liver, lung, skeletal muscle, kidney, pancreas and placenta.Synonyms: Homeobox protein Hox-1F, Homeobox protein Hox-A1
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基因ID
- 3198
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NCBI登录号
- NP_005513
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UniProt
- P49639
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途径
- Sensory Perception of Sound
抗原
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