DOCK1 抗体
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北京 101111
Quick Overview for DOCK1 抗体 (ABIN499057)
抗原
See all DOCK1 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of DOCK 180 protein. (region surrounding Lys1692)
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交叉反应 （详细）
- Species reactivity (tested):Human, Mouse.
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纯化方法
- Affinity chromatography
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纯度
- > 95 % by SDS-PAGE
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anti-Dedicator of Cytokinesis 1 (DOCK1) (AA 1676-1865) antibody
DOCK1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Dedicator of Cytokinesis 1 (DOCK1) (C-Term) antibodyDOCK1 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dedicator of Cytokinesis 1 (DOCK1) (C-Term) antibodyDOCK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dedicator of Cytokinesis 1 (DOCK1) (AA 698-803) antibodyDOCK1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D10 unconjugated
anti-Dedicator of Cytokinesis 1 (DOCK1) (C-Term) antibodyVerified DOCK1 适用: 人 WB 宿主: 山羊 Polyclonal unconjugated
anti-Dedicator of Cytokinesis 1 (DOCK1) (AA 100-1732) antibodyDOCK1 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Dedicator of Cytokinesis 1 (DOCK1) (AA 1200-1435) antibodyDOCK1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- DOCK1 (Dedicator of Cytokinesis 1 (DOCK1))
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别名
- DOCK1 / DOCK180
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背景
- The v-Crk oncogene product shares homologous amino acid sequences, designated Src homology region 2 (SH2) and SH3, with many molecules involved in signal transduction. The v-Crk cellular homolog, c-Crk, is a member of a newly emerging class of genes including Nck and GRB2/ASH which encode proteins that consist primarily of SH2 and SH3 domains. Two distinct human c-Crk cDNAs, designated Crk I and Crk II, have been identified and shown to represent alternative splice products of c-Crk. The major translational product of c-Crk I has been identified as a 28 kDa variably expressed protein, while c-Crk II encodes a widely expressed 40 kDa protein and a more variably expressed 42 kDa protein. The major c-Crk transforming activity appears associated with c-Crk I p28 expression. DOCK 180, a 180 kDa protein downstream of Crk, has been identified as a major Crk-associated protein. When DOCK 180 is recruited to the plasma membrane from a cytoplasmic reservoir, presumably by Crk, changes in cellular morphology and spindle formation occur, suggesting DOCK 180 to be a Crk effector molecule.Synonyms: 180 kDa protein downstream of CRK, Dedicator of cytokinesis protein 1
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分子量
- approx. 215 kDa
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基因ID
- 1793
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NCBI登录号
- NP_001371
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UniProt
- Q14185
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途径
- Signaling of Hepatocyte Growth Factor Receptor
抗原
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