PAR1 抗体
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北京 101111
Quick Overview for PAR1 抗体 (ABIN498947)
抗原
See all PAR1 (F2R) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of Thrombin R protein. (region surrounding Ser42)
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纯化方法
- Affinity chromatography
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纯度
- > 95 % by SDS-PAGE
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anti-Coagulation Factor II (thrombin) Receptor (F2R) (AA 251-350) antibody
F2R 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor II (thrombin) Receptor (F2R) (AA 61-76), (Extracellular), (N-Term) antibodyF2R 适用: 人 WB, IHC, FACS, IF, LCI, IC 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor II (thrombin) Receptor (F2R) (N-Term) antibodyF2R 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor II (thrombin) Receptor (F2R) (AA 42-102) antibodyF2R 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 2C5 unconjugated
anti-Coagulation Factor II (thrombin) Receptor (F2R) (AA 42-176) antibodyF2R 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 5E2E6 unconjugated
anti-Coagulation Factor II (thrombin) Receptor (F2R) (AA 1-425) antibodyF2R 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Coagulation Factor II (thrombin) Receptor (F2R) (AA 42-102) antibodyF2R 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor II (thrombin) Receptor (F2R) (AA 130-425) antibodyF2R 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor II (thrombin) Receptor (F2R) (AA 66-80), (Extracellular), (N-Term) antibodyF2R 适用: 小鼠 WB, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor II (thrombin) Receptor (F2R) (Internal Region) antibodyVerified F2R 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
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Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- PAR1 (F2R) (Coagulation Factor II (thrombin) Receptor (F2R))
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别名
- Thrombin Receptor / F2R
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背景
- Thrombin is a serine protease that is involved in platelet aggregation and blood coagulation. It is cleaved from its precursor, prothrombin, and converts fibrinogen to fibrin in the final step of the clotting cascade. Thrombin mediates its regulatory effects by activating cell surface receptors. These receptors, including thrombin receptor (also designated PAR-1, for protease-activated receptor-1), PAR-2 and PAR-3 are members of the G-protein coupled receptor family, and share a similiar gene structure. Thrombin cleaves its receptor, releasing a 41 amino acid peptide which acts as a platelet agonist. Upon this activation by thrombin, the thrombin receptors trigger an increase in cytosolic Ca2+ concentration. Unactivated thrombin receptor cycles between the cell surface and an intracellular pool, while activated receptor internalizes rapidly and is degraded in the lysosomes. The human thrombin receptor is also known to be regulated by Sp1 and Sp3 transcription factors.Synonyms: CF2R, Coagulation factor II receptor, PAR-1, PAR1, Proteinase-activated receptor 1
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分子量
- approx. 48 kDa
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基因ID
- 2149
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NCBI登录号
- NP_001983
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UniProt
- P25116
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途径
- Nuclear Receptor Transcription Pathway, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus
抗原
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