Merlin 抗体 (pSer518)
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北京 101111
Quick Overview for Merlin 抗体 (pSer518) (ABIN498767)
抗原
See all Merlin (NF2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer518
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特异性
- This antibody detects endogenous levels of p-NF2 protein only when phosphorylated at Ser518.
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- Affinity chromatography
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纯度
- > 95 % by SDS-PAGE
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anti-Neurofibromin 2 (NF2) (AA 477-576) antibody
NF2 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) antibodyKD Validated NF2 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB2620 unconjugated Recombinant Antibody
anti-Neurofibromin 2 (NF2) (AA 30-239) antibodyNF2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 30-311) antibodyNF2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 1-507) antibodyNF2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (pSer518) antibodyNF2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 230-414) antibodyNF2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (pSer518) antibodyNF2 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 65-95), (N-Term) antibodyNF2 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB19187 unconjugated
anti-Neurofibromin 2 (NF2) (C-Term) antibodyNF2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western Blot: 1/500 - 1/1000. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Merlin (NF2) (Neurofibromin 2 (NF2))
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别名
- Merlin
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背景
- Neurofibromatosis type 2 (NF2) is a dominantly inherited disorder characterized by the occurance of bilateral vestibular schwannomas and other central nervous system tumors, including multiple meningiomas. NF2 occurs in about 1 of 40,000 live births. The NF2 gene is highly penetrant, NF2-affected individuals have a 95 % chance of developing bilateral vestibular schwannomas. NF2 is distinct from NF1, which is characterized by an incidence of 1 in 4000, maps to chromosome 17 and encodes a protein designated neurofibromin, which is a large protein with a GAP domain. Genetic linkage studies of both sporadic and familial tumors suggest that NF2 is caused by inactivation of a tumor suppressor gene that maps on chromosome 22q12 and encodes a 595 amino acid protein whose function appears to be mediated by interaction with the cytoskeleton.Synonyms: Moesin-ezrin-radixin-like protein, NF2, Neurofibromin-2, SCH, Schwannomerlin, Schwannomerlin, Schwannomin, Schwannomin
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分子量
- approx. 70 kDa
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基因ID
- 4771
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NCBI登录号
- NP_000259
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UniProt
- P35240
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途径
- Cell-Cell Junction Organization
抗原
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