FOXO4 抗体 (pSer197)
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Quick Overview for FOXO4 抗体 (pSer197) (ABIN498704)
抗原
See all FOXO4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer197
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特异性
- This antibody detects endogenous levels of AFX1 protein only when phosphorylated at Ser197.
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交叉反应 （详细）
- Species reactivity (tested):Human, Mouse.
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纯化方法
- Affinity chromatography
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纯度
- > 95 % by SDS-PAGE
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anti-Forkhead Box O4 (FOXO4) (pThr451) antibody
FOXO4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box O4 (FOXO4) (pSer197) antibodyFOXO4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box O4 (FOXO4) antibodyKD Validated FOXO4 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 23GB1470 unconjugated Recombinant Antibody
anti-Forkhead Box O4 (FOXO4) (N-Term) antibodyFOXO4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box O4 (FOXO4) (C-Term) antibodyFOXO4 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box O4 (FOXO4) antibodyKO Validated FOXO4 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB3445 unconjugated Recombinant Antibody
anti-Forkhead Box O4 (FOXO4) (pSer197) antibodyFOXO4 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box O4 (FOXO4) (AA 206-240) antibodyFOXO4 适用: 人 WB, IF 宿主: 兔 Polyclonal RB51229 unconjugated
anti-Forkhead Box O4 (FOXO4) (Internal Region) antibodyVerified FOXO4 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Forkhead Box O4 (FOXO4) (AA 45-63) antibodyFOXO4 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- FOXO4 (Forkhead Box O4 (FOXO4))
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别名
- FOXO4 / AFX1 / MLLT7
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背景
- FKHR (for forkhead in rhabdomyosarcoma), FKHRL1, and AFX1 are members of a subfamily of the forkhead family of transcription factors. AFX1, also known as FoxO4, is expressed in a wide variety of tissues and, like other FKHR proteins, AFX1 contains a single forkhead domain and serineproline-rich region, which mediate DNA binding. AFX1-mediated transcriptional activation is regulated by the serine/threonine kinase Akt1, which phosphorylates AFX1 (in humans, this phosphorylation can occur at several sites, including Ser 197) and in turn, sequesters AFX1 in the cytosol, thereby blocking nuclear localization and DNA binding. Genetic mutations in FKHR genes, including the t(2,13) and t(1,3) translocations, are commonly found in alveolar rhabdomyosarcomas. Additionally, the t(x,11) translocation of the AFX1 gene, which involves the fusion of a serine-prolinerich sequence of AFX1 to the carboxyterminus of a truncated MLL, results in acute lymphocytic leukemia.Synonyms: Fork head domain transcription factor AFX1, Forkhead box protein O4
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分子量
- approx. 55, 70 kDa
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基因ID
- 4303
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NCBI登录号
- NP_005929
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UniProt
- P98177
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途径
- Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation
抗原
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