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- 抗原 See all GUCY1A1 抗体
- GUCY1A1 (Guanylate Cyclase 1 Soluble Subunit Alpha (GUCY1A1))
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适用
- 人, 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GUCY1A1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- This antibody detects endogenous levels of GCS-alpha-1 protein. (region surrounding Asp423)
- 交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - 纯化方法
- Affinity chromatography
- 纯度
- > 95 % by SDS-PAGE
- Top Product
- Discover our top product GUCY1A1 Primary Antibody
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anti-Guanylate Cyclase 1 Soluble Subunit Alpha (GUCY1A1) (AA 22-214) antibody
GUCY1A1 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 3G6B2 unconjugated
anti-Guanylate Cyclase 1 Soluble Subunit Alpha (GUCY1A1) (AA 20-152) antibodyGUCY1A1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase 1 Soluble Subunit Alpha (GUCY1A1) (AA 269-300), (N-Term) antibodyGUCY1A1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB07757 unconjugated
anti-Guanylate Cyclase 1 Soluble Subunit Alpha (GUCY1A1) antibodyGUCY1A1 适用: 人, 大鼠, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase 1 Soluble Subunit Alpha (GUCY1A1) (AA 1-690) antibodyGUCY1A1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase 1 Soluble Subunit Alpha (GUCY1A1) (AA 41-140) antibodyGUCY1A1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2H1 unconjugated
anti-Guanylate Cyclase 1 Soluble Subunit Alpha (GUCY1A1) (AA 1-120) antibodyGUCY1A1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase 1 Soluble Subunit Alpha (GUCY1A1) (AA 301-400) antibodyGUCY1A1 适用: 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase 1 Soluble Subunit Alpha (GUCY1A1) (Internal Region) antibodyGUCY1A1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase 1 Soluble Subunit Alpha (GUCY1A1) (AA 1-690) antibodyGUCY1A1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
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Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1,0 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH ~7.2, 15 mM Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- GUCY1A1 (Guanylate Cyclase 1 Soluble Subunit Alpha (GUCY1A1))
- 别名
- Guanylate Cyclase Soluble GUCY1A3 (GUCY1A1 产品)
- 别名
- GC-SA3 antibody, GUC1A3 antibody, GUCA3 antibody, GUCSA3 antibody, GUCY1A1 antibody, 1200016O07Rik antibody, Gucy1a1 antibody, SGC antibody, im:7136149 antibody, sgc1a1 antibody, zgc:112159 antibody, gucy1a3 antibody, guanylate cyclase 1 soluble subunit alpha antibody, guanylate cyclase 1, soluble, alpha 3 antibody, guanylate cyclase 1 soluble subunit alpha 3 antibody, soluble guanylyl cyclase alpha subunit antibody, GUCY1A3 antibody, Gucy1a3 antibody, gucy1a3 antibody
- 背景
- Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble form, known as GCS or sGC, act as receptors for nitric oxide. The membrane-bound receptor form, known as GC, are peptide hormone receptors. GCS is a cGMP-synthesizing enzyme, which is the major receptor for the neurotransmitter nitric oxide (NO). It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme containing heterodimer, consisting of one 72 kDa alpha subunit and one 65 kDa beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide, which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzylindazole, YC-1. YC-1 can also stimulate GCS in a NOindependent manner. Both alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both display similar enzymatic activity.Synonyms: GCS-alpha-1, GCS-alpha-3, GUC1A3, GUCSA3, GUCY1A1, Guanylate cyclase soluble subunit alpha-3, Soluble guanylate cyclase large subunit, sGC alpha
- 分子量
- approx. 77 kDa
- 基因ID
- 2982
- NCBI登录号
- NP_000847
- UniProt
- Q02108
- 途径
- Myometrial Relaxation and Contraction
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