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GAP43 抗体

The 兔 多克隆 anti-GAP43 antibody (ABIN498648) specifically detects GAP43 in IHC (p). The antibody is reactive with 人, 大鼠 和 小鼠 samples.
产品编号 ABIN498648
发货至: 中国
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Quick Overview for GAP43 抗体 (ABIN498648)

抗原

See all GAP43 抗体
GAP43 (Growth Associated Protein 43 (GAP43))

适用

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人, 大鼠, 小鼠

宿主

  • 121
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克隆类型

  • 100
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多克隆

标记

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This GAP43 antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 特异性

    This antibody detects endogenous levels of GAP43 protein. (region surrounding Ala35)

    交叉反应 (详细)

    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.

    纯化方法

    Affinity chromatography

    纯度

    > 95 % by SDS-PAGE
  • 应用备注

    Immunohistochemistry: 1/50 - 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    1,0 mg/mL

    缓冲液

    Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原

    GAP43 (Growth Associated Protein 43 (GAP43))

    别名

    GAP43

    背景

    GAP-43 (growth associated protein 43, B-50, PP46, calmodulin-binding protein P-57, neuromodulin, neuron growth-associated protein 43, protein F1) is a crucial component for regenerative response in the nervous system that is present at high levels in neuronal growth cones during development and axonal regeneration. GAP-43 is normally produced by neurons during developmental growth and axonal regeneration, but it is also expressed in specific regions of the normal adult nervous system. The neuron-specific ELAV/Hu family member, HuD, interacts with and stabilizes GAP-43 mRNA in developing neurons and leads to increased levels of GAP-43 protein. Heterozygous GAP-43 knockout mice with GAP-43 levels reduced by one-half display significant memory impairments in cued conditioning or on tests of nociceptive or auditory perception.Synonyms: Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-50, Neuromodulin, PP46

    分子量

    approx. 38, 43 kDa

    基因ID

    2596

    NCBI登录号

    NP_002036

    UniProt

    P17677
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