IL5RA 抗体
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Quick Overview for IL5RA 抗体 (ABIN498570)
抗原
See all IL5RA 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of IL-5Ralpha protein. (region surrounding Lys68)
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交叉反应 （详细）
- Species reactivity (tested):Human, Mouse.
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纯化方法
- Affinity Chromatography using epitope-specific immunogen
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anti-Interleukin 5 Receptor, alpha (IL5RA) (AA 41-203) antibody
IL5RA 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 5 Receptor, alpha (IL5RA) (AA 21-196) antibodyIL5RA 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 5E12F5D6 unconjugated
anti-Interleukin 5 Receptor, alpha (IL5RA) (AA 42-182) antibodyIL5RA 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 5 Receptor, alpha (IL5RA) (AA 49-76), (N-Term) antibodyIL5RA 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB26162 unconjugated
anti-Interleukin 5 Receptor, alpha (IL5RA) antibodyIL5RA 适用: 人, 小鼠 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 5 Receptor, alpha (IL5RA) (AA 1-335) antibodyIL5RA 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Interleukin 5 Receptor, alpha (IL5RA) (AA 20-335) antibodyIL5RA 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 5 Receptor, alpha (IL5RA) antibodyIL5RA 适用: 人 FACS 宿主: Human, 兔 Chimeric DMC393 unconjugated Fc fragment Recombinant Antibody
anti-Interleukin 5 Receptor, alpha (IL5RA) antibodyIL5RA 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- IL5RA (Interleukin 5 Receptor, alpha (IL5RA))
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别名
- CD125 / IL5RA
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背景
- Interleukin 5 (IL-5) is a soluble T cell-derived factor, also known as T cellreplacing factor (TRF), that induces B cell and eosinophil growth and differentiation. IL-5 exerts its biological activity through the IL-5 receptor (IL-5R), which is composed of two chains: an alpha chain that binds IL-5 with low affinity and a beta chain that does not bind IL-5, but together with the IL-5 alpha chain, constitutes the high affinity IL-5 receptor. The cytoplasmic domain of both the alpha and beta chains is essential for signal transduction. Specifically, the membraneproximal proline-rich sequence of the cytoplasmic domain of the IL-5R receptor alpha subunit, IL-5Ralpha, is critical for the IL-5 induced proliferative response, expression of nuclear protooncogenes and tyrosine phosphorylation of cellular proteins, such as JAK1 and JAK2. Alternative splicing of the IL-5Ralpha gene produces several isoforms, including a membraneanchored isoform and a soluble isoform. The soluble isoform competes with IL-5 for binding to IL-5R and inhibits IL-5-mediated receptor activation and inflammatory mediator production, and, therefore, may be useful in treating asthma.Synonyms: IL-5R-alpha, IL5 Receptor alpha, Interleukin-5 receptor subunit alpha
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基因ID
- 3568
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NCBI登录号
- NP_000555
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UniProt
- Q01344
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途径
- JAK/STAT Signaling
抗原
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