GAL4 抗体
Our Local Distributor
北京 101111
Quick Overview for GAL4 抗体 (ABIN498445)
抗原
See all GAL4 (LGALS4) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
特异性
- This antibody detects endogenous levels of Galectin-4 protein. (region surrounding Lys83)
-
交叉反应 (详细)
- Species reactivity (tested):Human.
-
纯化方法
- Affinity chromatography
-
纯度
- > 95 % by SDS-PAGE
-
-
-
-
应用备注
-
Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
浓度
- 1,0 mg/mL
-
缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
-
- GAL4 (LGALS4) (Galectin 4 (LGALS4))
-
别名
- Galectin-4
-
背景
- Galectins are a family of soluble beta-galactoside-binding animal lectins that modulate cell-to-cell adhesion and cell-to-extracellular matrix (ECM) interactions and play a role in tumor progression, pre-mRNA splicing and apoptosis. One member of this family, Galectin-4, also known as Gal-4, L36 or LGALS4 maps to human chromosome 19q13.13 and encodes a 36-37 kDa protein. The Galectin-4 protein is composed of 323 amino acids and contains two homologous carbohydrate recognition domains (CRD) and all amino acids typically conserved in the galectin family. Expression of Galectin-4 correlates with the malignant potential of human hepatocellular carcinoma (HCC) and is differentially regulated depending on cell-cell contact, serum growth factors, cell growth and cell differentiation status. Galectin-4 expression is detected in epithelial cells of the colon, rectum, intestine, and in HT29 and LS174T cell lines. Galectin-4 is underexpressed in colorectal cancer and is preferentially upregulated in cells prone to peritoneal dissemination.Synonyms: Antigen NY-CO-27, Galectin4, L-36 lactose-binding protein, L36LBP, LGALS4, Lactose-binding lectin 4
-
分子量
- approx. 36 kDa
-
基因ID
- 3960
-
NCBI登录号
- NP_006140
-
UniProt
- P56470
抗原
-