TIMP3 抗体
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北京 101111
Quick Overview for TIMP3 抗体 (ABIN498405)
抗原
See all TIMP3 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of TIMP-3 protein. (region surrounding asn119)
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- Affinity Chromatography using epitope-specific immunogen.
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anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 151-211) antibody
TIMP3 适用: 人, 大鼠, 兔 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 26-211) antibodyTIMP3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 113-139) antibodyTIMP3 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21049 unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 170-188) antibodyTIMP3 适用: 人, Cow, 犬, 马, 绵羊, Pig, 猴 WB, IHC, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 27-209) antibodyTIMP3 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 119-148), (Middle Region) antibodyTIMP3 适用: 人 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 176-210), (C-Term) antibodyTIMP3 适用: 人 WB 宿主: 兔 Polyclonal RB47669 unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 112-211) antibodyTIMP3 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1D8 unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (N-Term) antibodyTIMP3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 175-211) antibodyTIMP3 适用: 人, 小鼠, 大鼠, Cow, 犬, 马 IHC, FACS, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate Buffered Saline (PBS), pH ~7.2, 0.05 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- TIMP3 (TIMP Metallopeptidase Inhibitor 3 (TIMP3))
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别名
- TIMP3
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背景
- The tissue inhibitors of metalloproteinases (TIMPs) are naturally occurring proteins that specifically inhibit matrix metalloproteinases and regulate extracellular matrix turnover and tissue remodeling by forming tightly bound inhibitory complexes with the MMPs. Thus, TIMPs maintain the balance between matrix destruction and formation. An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. TIMP proteins share several structural features including six loops held in place by six disulfide bonds arranged in three knotlike structures. The N terminal region is necessary for inhibitory activity. The N terminus of each TIMP contains a consensus sequence (VIRAK) and each TIMP is translated with a 29 amino acid leader sequence that is cleaved to produce the mature protein. The C terminal regions are divergent and enhance the inhibition selectivity and binding efficiency. Although the TIMP proteins share high homology, following secretion they are localized extracellularly either in soluble form (TIMP1, TIMP2, and TIMP4) or bound to extracellular matrix components (TIMP3).Synonyms: Metalloproteinase inhibitor 3, Protein MIG-5, TIMP-3, Tissue inhibitor of metalloproteinases 3
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分子量
- approx. 25 kDa
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基因ID
- 7078
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NCBI登录号
- NP_000353
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UniProt
- P35625
抗原
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