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- 抗原 See all ADCY1 抗体
- ADCY1 (Adenylate Cyclase 1 (Brain) (ADCY1))
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ADCY1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- This antibody detects endogenous levels of A Cyclase I protein. (region surrounding Asp252)
- 交叉反应 （详细）
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Species reactivity (expected):Mouse.
Species reactivity (tested):Human. - 纯化方法
- Affinity chromatography
- 纯度
- > 95 % by SDS-PAGE
- Top Product
- Discover our top product ADCY1 Primary Antibody
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anti-Adenylate Cyclase 1 (Brain) (ADCY1) (AA 751-850) antibody
ADCY1 适用: 人, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Adenylate Cyclase 1 (Brain) (ADCY1) antibodyADCY1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adenylate Cyclase 1 (Brain) (ADCY1) antibodyADCY1 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Adenylate Cyclase 1 (Brain) (ADCY1) (AA 835-1061) antibodyADCY1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Adenylate Cyclase 1 (Brain) (ADCY1) (AA 416-610) antibodyADCY1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Adenylate Cyclase 1 (Brain) (ADCY1) (Internal Region) antibodyADCY1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adenylate Cyclase 1 (Brain) (ADCY1) (AA 231-280) antibodyADCY1 适用: 人, 小鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Adenylate Cyclase 1 (Brain) (ADCY1) (AA 897-1136) antibodyADCY1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adenylate Cyclase 1 (Brain) (ADCY1) antibodyADCY1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Adenylate Cyclase 1 (Brain) (ADCY1) (AA 470-610) antibodyADCY1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Western Blot: 1/500- 1/1000. Immuohistochemistry: 1/50- 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1,0 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- ADCY1 (Adenylate Cyclase 1 (Brain) (ADCY1))
- 别名
- Adenylate Cyclase Type 1 (ADCY1 产品)
- 别名
- AC1 antibody, D11Bwg1392e antibody, I-AC antibody, brl antibody, mKIAA4070 antibody, Ac1 antibody, adenylate cyclase 1 antibody, adenylate cyclase type 1 antibody, adenylate cyclase 1 (brain) antibody, ADCY1 antibody, LOC100449504 antibody, adcy1 antibody, Adcy1 antibody
- 背景
- Adenylyl cyclases function to convert ATP to cyclic AMP in response to activation by a variety of hormones, neurotransmitters and other regulatory molecules. Cyclic AMP, in turn, activates several other target molecules to control a broad range of diverse phenomena such as metabolism, gene transcription and memory. Adenylyl cyclases respond to receptor-initiated signals, mediated by the Gs and Gi heterotrimeric G proteins. The binding of an agonist to a Gs-coupled receptor catalyzes the exchange of GDP (bound to Galpha s) for GTP, the dissociation of GTP-Galpha s from Gbeta-gamma and Galpha s)-mediated activation of adenylyl cyclase. Adenylyl cyclases type I (AC I) and III (AC III) have distinct staining within the cell nucleus of rat brain sensory neurons. AC I is expressed in myenteric ganglia as two bands of 160 kDa and 185 kDa by SDS-PAGE. Ca2+ stimulation of AC I and AC III is mediated by calmodulin. Protein associated with Myc (PAM) is a very potent inhibitor of AC I. A decrease in endogenous PAM levels in HeLa cells modulate both basal and agonist stimulated cAMP accumulation.Synonyms: ADCY1, ATP pyrophosphate-lyase 1, Adenylate cyclase type I, Adenylyl cyclase 1, Ca(2+)/calmodulin-activated adenylyl cyclase
- 分子量
- approx. 130 kDa
- 基因ID
- 107
- NCBI登录号
- NP_066939
- UniProt
- Q08828
- 途径
- EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, cAMP Metabolic Process, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
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