CCAR2 抗体
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北京 101111
Quick Overview for CCAR2 抗体 (ABIN498347)
抗原
See all CCAR2 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of KIAA1967 / DBC-1 protein. (region surrounding Gln455)
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交叉反应 （详细）
- Species reactivity (tested):Human.
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纯化方法
- Affinity chromatography
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纯度
- > 95 % pure SDS-PAGE
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anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) antibody
CCAR2 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 1A9G12 unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) (AA 65-917) antibodyCCAR2 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) (AA 1-923) antibodyCCAR2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) (AA 1-923) antibodyCCAR2 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) (AA 654-923) antibodyCCAR2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) (AA 5-365) antibodyCCAR2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4E6 unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) (Internal Region) antibodyCCAR2 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) antibodyCCAR2 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 25GB70 unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) antibodyCCAR2 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) (AA 842-855) antibodyVerified CCAR2 适用: 人, 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
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Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS) with 15 mM Sodium azide, approx. pH 7.2.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- CCAR2 (Cell Cycle and Apoptosis Regulator 2 (CCAR2))
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别名
- KIAA1967
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背景
- KIAA1967 / DBC-1 (deleted in breast cancer gene 1 protein), also known as p30 DBC protein, is one of the genes located within the region of chromosome 8 (8p21-8p23) that is homozygously deleted in some breast cancers. DBC-1 contains a nuclear localization signal, an N-terminal leucine zipper, an EF hand and a C-terminal coiled-coil region. DBC-1 is closely related to DIS but lacks the SAP domain. During death signaling mediated by TNFα, endogenous DBC-1 undergoes caspase-dependent processing to generate DBC-1 p120 and p66, both of which include the C-terminus of the protein. Both DBC-1 p120 and p66 relocate to the cytoplasm. Overexpression of the DBC-1 p120 form results in mitochondrial clustering and matrix condensation and increases the sensitivity of cells to TNFalpha-mediated apoptosis. In addition, DBC-1 directly interacts with unliganded ERalpha, stabilizing its expression and therefore collaborating to suppress apoptosis and promote hormone-independent cell growth.Synonyms: DBC-1, DBC.1, DBC1, Deleted in breast cancer gene 1 protein, KIAA1967, p30 DBC
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分子量
- approx. 102.0 kDa
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基因ID
- 57805
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NCBI登录号
- NP_066997
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UniProt
- Q8N163
抗原
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