TRF1 抗体
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北京 101111
Quick Overview for TRF1 抗体 (ABIN498269)
抗原
See all TRF1 (TERF1) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of TRF1 protein.
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交叉反应 （详细）
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Species reactivity (expected):Mouse.
Species reactivity (tested):Human. -
纯化方法
- Affinity chromatography using epitope-specific immunogen
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纯度
- > 95 % (by SDS-PAGE)
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anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) (AA 148-428) antibody
TERF1 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) (AA 240-419) antibodyTERF1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) (AA 1-439) antibodyTERF1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) antibodyTERF1 适用: 人 ELISA, IHC, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal BED5 unconjugated
anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) (AA 260-439) antibodyTERF1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) (C-Term) antibodyVerified TERF1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) (pSer219) antibodyTERF1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) (pSer219) antibodyTERF1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) (AA 260-439) antibodyTERF1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- TRF1 (TERF1) (Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1))
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别名
- TERF1
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背景
- Telomeric repeat binding factor 1 (TRF1, TERF1, PIN2, TRBF1) and telomeric repeat binding factor 2 (TRF2, TERF2, TRBF2) are present at telomeres throughout the cell cycle, where they regulate telomerase by acting in cis to limit the elongation of individual chromosome ends. Telomerase adds hexameric repeats of 5'-TTAGGG-3' to the ends of chromosomal DNA. This telomerase enzyme plays an influential role in cellular immortalization and cellular senescence. TRF1 negatively regulates telomere elongation, while TRF2 protects the chromosome ends by inhibiting end-to-end fusions. Downregulation of TRF expression in tumor cells may contribute to cell immortalization and malignant progression. TRF1 has an acidic N-terminus while TRF2 has a basic N-terminus. TRF2 localizes in the nucleolus at G0 and S and diffuses out of the nucleolus in G2 phase. During mitosis TRF2 disperses from the condensed chromosomes and returns to the nucleolus at cytokinesis.Synonyms: NIMA-interacting protein 2, PIN2, TRBF1, TRF, TRF1, TTAGGG repeat-binding factor 1, Telomeric protein Pin2/TRF1, Telomeric repeat-binding factor 1
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分子量
- approx. 50 kDa
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基因ID
- 7013
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NCBI登录号
- NP_003209
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UniProt
- P54274
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途径
- Cell Division Cycle, Telomere Maintenance, Hormone Transport, Chromatin Binding, Regulation of Cell Size, Positive Regulation of Endopeptidase Activity
抗原
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