SNAIL 抗体
(6 references)Quick Overview for SNAIL 抗体 (ABIN498268)
抗原
See all SNAIL (SNAI1) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
特异性
- This antibody detects endogenous levels of SNAI 1 protein. (region surrounding Ala242)
-
交叉反应 （详细）
-
Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human. -
纯化方法
- Affinity Chromatography using epitope-specific immunogen.
-
-
anti-SNAIL (SNAI1) (AA 1-100) antibody
SNAI1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SNAIL (SNAI1) (C-Term) antibodySNAI1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-SNAIL (SNAI1) (C-Term) antibodySNAI1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-SNAIL (SNAI1) (N-Term) antibodySNAI1 适用: 人, 小鼠, 大鼠, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-SNAIL (SNAI1) (AA 121-230) antibodySNAI1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2G11 unconjugated
anti-SNAIL (SNAI1) (AA 1-264) antibodySNAI1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-SNAIL (SNAI1) (AA 9-39), (N-Term) antibodySNAI1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB01400 unconjugated
anti-SNAIL (SNAI1) antibodySNAI1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-SNAIL (SNAI1) antibodySNAI1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SNAIL (SNAI1) antibodySNAI1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200. Immunoflourescence: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
浓度
- 1.0 mg/mL
-
缓冲液
- Phosphate buffered saline (PBS), pH 7.2, 0.05 % Sodium Azide
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
-
-
: "EGFR inhibition prevents in vitro tumor growth of salivary adenoid cystic carcinoma." in: BMC cell biology, Vol. 14, pp. 13, (2013) (PubMed).
: "A novel role of ribonuclease inhibitor in regulation of epithelial-to-mesenchymal transition and ILK signaling pathway in bladder cancer cells." in: Cell and tissue research, Vol. 353, Issue 3, pp. 409-23, (2013) (PubMed).
: "Up-regulating ribonuclease inhibitor inhibited epithelial-to-mesenchymal transition and metastasis in murine melanoma cells." in: The international journal of biochemistry & cell biology, Vol. 44, Issue 6, pp. 998-1008, (2012) (PubMed).
: "Protein kinase CK2? is overexpressed in colorectal cancer and modulates cell proliferation and invasion via regulating EMT-related genes." in: Journal of translational medicine, Vol. 9, pp. 97, (2011) (PubMed).
: "Aberrant expression of chemokine receptor CCR4 in human gastric cancer contributes to tumor-induced immunosuppression." in: Cancer science, Vol. 102, Issue 7, pp. 1264-71, (2011) (PubMed).
: "PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development." in: Molecular and cellular biology, Vol. 30, Issue 14, pp. 3711-21, (2010) (PubMed).
-
: "EGFR inhibition prevents in vitro tumor growth of salivary adenoid cystic carcinoma." in: BMC cell biology, Vol. 14, pp. 13, (2013) (PubMed).
-
- SNAIL (SNAI1)
-
别名
- SNAI1
-
背景
- The SNAIL family of developmental regulatory proteins is a group of widely conserved zinc-finger proteins that regulate transcription and include the mammalian proteins SLUG, SNAI 1, the human homolog of Drosophila SNAIL, and Smuc. SNAI 1 and SLUG are expressed in placenta and adult heart, liver and skeletal muscle. SNAI 1, and the corresponding mouse homolog Sn,a each contain three classic zinc fingers and one atypical zinc finger, while SLUG contains five zinc finger regions and a transcriptional repression domain at the amino terminus, which enables SLUG to act as a negative regulator of gene expression. SLUG is implicated in the generation and migration of neural crest cells in human embryos and also contributes to limb bud development. In addition, SLUG also constitutes a cellular anti-apoptotic transcription factor that effectively prevents apoptosis in murine pro-B cells deprived of IL-3. The SNAIL-related gene from murine skeletal muscle cells, Smuc, is highly expressed in skeletal muscle and thymus and can, likewise, repress gene transcription. Smuc preferentially associates with CAGGTG and CACCTG E-box motifs (CANNTG) on DNA and involves the five putative DNA-binding zinc finger domains at the C-terminal region of Smuc.Synonyms: Protein snail homolog 1, SNAH, Zinc finger protein SNAI1
-
分子量
- approx. 29 kDa
-
基因ID
- 6615
-
NCBI登录号
- NP_005976
-
UniProt
- O95863
-
途径
- Negative Regulation of intrinsic apoptotic Signaling
抗原
-
