KCNJ3 抗体
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北京 101111
Quick Overview for KCNJ3 抗体 (ABIN498130)
抗原
See all KCNJ3 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of KIR3.1 protein.
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- Affinity chromatography using epitope-specific immunogen
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纯度
- > 95 % (by SDS-PAGE)
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anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 (KCNJ3) (AA 279-501) antibody
KCNJ3 适用: 人, 小鼠, 猴 WB, IF, IHC, FACS, IHC (p) 宿主: 小鼠 Monoclonal 3E11 unconjugated
anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 (KCNJ3) (AA 81-180) antibodyKCNJ3 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 (KCNJ3) (Internal Region) antibodyKCNJ3 适用: 人, 小鼠, 大鼠 WB, IF, ELISA, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 (KCNJ3) (AA 350-487) antibodyKCNJ3 适用: 人 IF, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 (KCNJ3) (Center) antibodyKCNJ3 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 (KCNJ3) (AA 151-200), (pSer185) antibodyKCNJ3 适用: 人, 小鼠, 大鼠 WB, IF, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 (KCNJ3) (Ser685) antibodyKCNJ3 适用: 人, 小鼠, 大鼠 WB, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 (KCNJ3) (Internal Region) antibodyKCNJ3 适用: 人, 小鼠, 大鼠, 猴, Cow, 豚鼠, 马, Pig, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 (KCNJ3) (AA 361-410) antibodyKCNJ3 适用: 人, 小鼠, 大鼠, 猴, Cow, 豚鼠, 马, Pig, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 (KCNJ3) (AA 390-418), (C-Term) antibodyKCNJ3 适用: 人, 小鼠 WB 宿主: 小鼠 Monoclonal 383CT22-2-1 unconjugated
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应用备注
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Western blot: 1: 500 - 1: 1000. Immunoflourescence: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- KCNJ3 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 (KCNJ3))
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别名
- KCNJ3
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背景
- G protein-coupled inwardly rectifying potassium channels (KIR3.1 through KIR3.4) are coupled to numerous neurotransmitter receptors in the brain and are abundantly expressed in the olfactory bulb, hippocampus, neocortex, dentate gyrus, cerebellar cortex and thalamus regions of the brain. Also known as GIRK, KIR3 potassium channels localize to the soma and dendrites as well as axons of neurons. Liberated Gbγ subunits from G protein heterotrimers bind to and regulate KIR3 channel activity. Gb3- and Gb4-containing Gbγ dimers bind directly to cytoplasmic domains of KIR3 proteins and increase the K+ current while Gb5-containing Gbγ dimers inhibit KIR3 K+ current. KIR3 activity is also inhibited by tyrosine phosphorylation. Brain-derived neurotrophic factor activates receptor tyrosine kinase B, which then phosphorylates KIR3 tyrosine residues, effectively inactivating the KIR3 channels.Synonyms: G protein-activated inward rectifier potassium channel 1, GIRK1, Inward rectifier K(+) channel Kir3.1, Potassium channel, inwardly rectifying subfamily J member 3
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分子量
- approx. 43 kDa
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基因ID
- 3760
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NCBI登录号
- NP_002230
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UniProt
- P48549
抗原
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