TAO Kinase 1 (TAOK1) (C-Term) 抗体
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Quick Overview for TAO Kinase 1 (TAOK1) (C-Term) 抗体 (ABIN498003)
抗原
See all TAO Kinase 1 (TAOK1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- Reacts with TAO Kinase 1 (TAOK1).
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交叉反应 （详细）
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Species reactivity (expected):Rat.
Species reactivity (tested):Human. -
纯化方法
- Immunoaffinity Chromatography.
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免疫原
- TAOK1 antibody was raised against synthetic peptide from human TAOK1. .Remarks: Rat Identity: 100% Rat Similarity: 100%
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亚型
- IgG
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anti-TAO Kinase 1 (TAOK1) (AA 892-1001) antibody
TAOK1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4E12 unconjugated
anti-TAO Kinase 1 (TAOK1) (C-Term) antibodyTAOK1 适用: 人, 小鼠, 大鼠, 猴, Cow, 犬, 马, Pig, 非洲爪蟾, Bat, Hamster, 兔, 小鸡 ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-TAO Kinase 1 (TAOK1) (AA 400-659) antibodyTAOK1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TAO Kinase 1 (TAOK1) (Internal Region) antibodyTAOK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-TAO Kinase 1 (TAOK1) antibodyTAOK1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB2320 unconjugated Recombinant Antibody
anti-TAO Kinase 1 (TAOK1) (AA 400-450) antibodyTAOK1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-TAO Kinase 1 (TAOK1) (AA 620-650) antibodyTAOK1 适用: 人 WB 宿主: 兔 Polyclonal RB9765 unconjugated
anti-TAO Kinase 1 (TAOK1) (AA 431-480) antibodyTAOK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-TAO Kinase 1 (TAOK1) (Internal Region) antibodyTAOK1 适用: 人, 猴 IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-TAO Kinase 1 (TAOK1) (C-Term) antibodyTAOK1 适用: 人, 小鼠, 大鼠, 猴, 非洲爪蟾 ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunohistochemistry on Formalin Fixed Paraffin Embedded Tissues: 5 μg/mL (Requirespretreatment with Proteinase K).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS containing 0.09 % Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.
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- TAO Kinase 1 (TAOK1)
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背景
- TAOK1 is an upstream activator of Mark. TAOK1 phosphorylated Mark on a threonine within its activation loop. In brain, TAOK1 also phosphorylated a fraction of Mark on a nearby serine, and this phosphorylation inhibited Mark activity. In cells, TAOK1 activity enhanced microtubule dynamics through activation of Mark and led to phosphorylation and detachment of microtubule-associated proteins from microtubules. TAOK1 also activated JNK in vitro. Overexpression of TAOK1 in a human nonsmall cell lung carcinoma cell line induced apoptotic morphologic changes, including cell contraction, membrane blebbing, and apoptotic body formation. Apoptotic stimuli increased the catalytic activity of endogenous TAOK1 and JNK, and dominant-negative JNK or JNK inhibition blocked the apoptotic morphologic responses to TAOK1. TAOK1 also stimulated cleavage and activation of ROCK1 by caspases, leading to cell contraction and membrane blebbing. TAOK1 was itself a substrate for caspase-3. TAOK1 is indeed involved in the execution phase of apoptosis.Synonyms: KFC-B, KIAA1361, Kinase from chicken homolog B, MAP3K16, STE20-like kinase PSK2, Serine/threonine-protein kinase TAO1, Thousand and one amino acid protein 1
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基因ID
- 57551
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NCBI登录号
- NP_065842
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UniProt
- Q7L7X3
抗原
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