Expected species reactivity: Rat, Bovine, Drosophila
纯化方法
Antigen affinity purified
免疫原
This WDR5 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 321-354 amino acids from the C-terminal region of human WDR5.
Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.