UBE2V1 抗体 (AA 113-145)
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Quick Overview for UBE2V1 抗体 (AA 113-145) (ABIN3029435)
抗原
See all UBE2V1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 113-145
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交叉反应 （详细）
- Expected species reactivity: Rat, Bovine, Chicken, Zebrafish, Xenopus
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纯化方法
- Purified
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免疫原
- A portion of amino acids 113-145 from the human protein was used as the immunogen for this UBE2V1 antibody.
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亚型
- Ig Fraction
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anti-Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1) (AA 1-147) antibody
UBE2V1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1) (AA 1-147) antibodyUBE2V1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1) antibodyUBE2V1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1) (AA 1-103) antibodyUBE2V1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1) (AA 2-147) antibodyUBE2V1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1) (C-Term) antibodyUBE2V1 适用: 人, 小鼠, 大鼠, Cow, 犬, 山羊, 马, Pig, 兔, Bat, 小鸡, 猴, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1) (AA 113-145), (C-Term) antibodyUBE2V1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB4387 unconjugated
anti-Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1) antibodyUBE2V1 适用: 人, 小鼠 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Titration of the UBE2V1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS pH 7.4 with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the UBE2V1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- UBE2V1 (Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1))
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别名
- UBE2V1
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背景
- The CROC1 isoforms, also known as UBE2V1, show sequence similarity to ubiquitin-conjugating enzymes (UBCs, or E2s) but lack the conserved cysteine residue critical to catalytic activity of E2s.1 Northern blot analysis detected approximately 2.1- and 2.5-kb CROC1 transcripts in all human tissues examined, with the highest levels in brain, skeletal muscle, and kidney. Partial human intestinal epithelial cell cDNAs have been isolated containing the 3-primecoding sequence and 3-prime untranslated region of UBE2V1, also called UEV1.2 UEV1 does not have ubiquitin-conjugating activity in vitro. UEV1 transcripts are downregulated upon differentiation of a colon carcinoma cell line.1 Constitutive expression of exogenous UEV1 protein in these colon carcinoma cells inhibits their capacity to differentiate upon confluence and induces changes in cell cycle behavior associated with inhibition of CDK1. A heterodimeric protein complex has been identified that links TRAF6 to IKK activation.3 Peptide mass fingerprinting analysis revealed that this complex is composed of the ubiquitin conjugating enzyme UBC13 and the UBC-like protein UBE2V1, also called UEV1A. TRAF6, a RING domain protein, functions together with UBC13/UEV1A to catalyze the synthesis of unique polyubiquitin chains linked through lysine-63 (K63) of ubiquitin. Blockade of this polyubiquitin chain synthesis, but not inhibition of the proteasome, prevents the activation of IKK by TRAF6. These results unveil a new regulatory function for ubiquitin, in which IKK is activated through the assembly of K63-linked polyubiquitin chains.
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UniProt
- Q13404
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途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
抗原
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