UBE2I 抗体 (AA 1-30)
Quick Overview for UBE2I 抗体 (AA 1-30) (ABIN3029438)
抗原
See all UBE2I 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1-30
-
交叉反应 (详细)
- Expected species reactivity: Mouse, Rat, Chicken, Zebrafish, Xenopus
-
纯化方法
- Purified
-
免疫原
- A portion of amino acids 1-30 from the human protein was used as the immunogen for this UBC9 antibody.
-
亚型
- Ig Fraction
-
-
-
-
应用备注
- Titration of the UBC9 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Aliquot the UBC9 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
-
-
- UBE2I (Ubiquitin-Conjugating Enzyme E2I (UBE2I))
-
别名
- UBC9
-
背景
- UBE2I (Ubc9) is a member of the E2 family and is specific for the conjugation of SUMO to a variety of target proteins. SUMO conjugation to target proteins is mediated by a different, but analogous, pathway to ubiquitinylation. This E2 is unusual in that it interacts directly with protein substrates that are modified by sumoylation, and may play a role in substrate recognition. UBE2I can mediate the conjugation of SUMO-1 to a variety of proteins including RanGAP1, I?B?, and PML without the requirement of an E3 ligase. UBE2I is essential for nuclear architecture and chromosome segregation.
-
UniProt
- P63279
-
途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Ubiquitin Proteasome Pathway
抗原
-