TLK2 抗体 (AA 141-171)
Our Local Distributor
北京 101111
Quick Overview for TLK2 抗体 (AA 141-171) (ABIN3029189)
抗原
See all TLK2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 141-171
-
纯化方法
- Purified
-
免疫原
- A portion of amino acids 141-171 from the human protein was used as the immunogen for this TLK2 antibody.
-
亚型
- Ig Fraction
-
-
-
-
应用备注
- Titration of the TLK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- In 1X PBS pH 7.4 with 0.09 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Aliquot the TLK2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
-
-
- TLK2 (Tousled-Like Kinase 2 (TLK2))
-
别名
- TLK2
-
背景
- TLK2, a member of the Ser/Thr protein kinase family, is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. The TLK2 enzyme is cell-cycle regulated, with maximal activity in S-phase. It is inactivated by phosphorylation at Ser-750, potentially by CHK1. TLK2 heterodimerizes with TLK1. This nuclear protein is widely expressed, with presence in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle tissues, and in several adult cell lines.
-
UniProt
- Q86UE8
抗原
-