SUV39H2 抗体 (AA 367-395)
Our Local Distributor
北京 101111
Quick Overview for SUV39H2 抗体 (AA 367-395) (ABIN3029053)
抗原
See all SUV39H2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 367-395
-
交叉反应 (详细)
- Expected species reactivity: Mouse, Primate
-
纯化方法
- Antigen affinity purified
-
免疫原
- A portion of amino acids 367-395 from the human protein was used as the immunogen for this SUV39H2 antibody.
-
亚型
- Ig Fraction
-
-
-
-
应用备注
- Titration of the SUV39H2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Aliquot the SUV39H2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
-
-
- SUV39H2 (Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2))
-
别名
- SUV39H2 (KTM1B)
-
背景
- Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher order chromatin organization during spermatogenesis.
-
UniProt
- Q9H5I1
抗原
-